literature

SARS_CoV_2 mutation literature information.

Complete genome sequencing of SARS-CoV-2 strains: A pilot survey in Palestine reveals spike mutation H245N.

PMID: 34949225 2021 BMC research notes

Introduction: All ten study genome sequences contained the spike mutation D614G which is the most prevalent mutation (90.2%) reported in 132 countries which has been shown to increase infectivity of the virus by increasing cellular transduction.

Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together.

PMID: 34956222 2021 Frontiers in immunology

Result: Antibody titers against four different SARS-CoV-2 spike versions (the full-length spike protein bearing the D614G substitution, the Spike-RBD, the RBD carrying the E484Q alteration, or the NTD) and the nucleocapsid protein (NCP) ( Table 2 ) were calculated using serum samples obtained from each cohort.

Result: Genotypic analysis of the SARS-CoV-2 virus present in baseline samples confirm absence of these SARS-CoV-2 variants in this cohort, with the majority of infecting viruses containing the Table: D614G

Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2.

PMID: 34957216 2021 Frontiers in molecular biosciences

Introduction: We identified some target mutations D614G, N501Y, and K417N in the South Africa, United Kingdom, and Brazil variants, respectively.

Result: D614G, the dominant variant of SARS-CoV-2, corresponds to D600G but was predicted to stabilize S (G = -0.784 kcal/mol).

Table: D614G

The Impact of Mutations on the Pathogenic and Antigenic Activity of SARS-CoV-2 during the First Wave of the COVID-19 Pandemic: A Comprehensive Immunoinformatics Analysis.

PMID: 34960156 2021 Vaccines

Introduction: Among these, the D614G mutation is responsible for increased transmissibility.

Introduction: However, few mutations, such as D614G in spike (S) and p323L in RdRp, have been rapidly evolving in SARS-CoV-2 genome.

Result: Among these pathogenic mutations, D614G (score = 4) in the S regio

Semi-Supervised Pipeline for Autonomous Annotation of SARS-CoV-2 Genomes.

PMID: 34960694 2021 Viruses

Abstract: We observed 3362 non-redundant sequences per protein on average within this corpus and described key D614G and N501Y variants spatiotemporally in the initial genome corpus.

Introduction: Additionally, several variants of SARS-CoV-2 genomes have emerged, including the D614G variant, which appeared earlier in the pandemic, or the more recent B.1.1.7 (Alpha) or B.1.617.2 (Delta) variants, which represent the majority of new cases in the U.S.A.

Introduction: Furthermore in a targeted analysis, we achieved greater than 97.9% sequence identity in spike glycoprotein domains and tracked the emergence of the D614G and N501Y spike glycoprotein variants over time and by region of exposure.

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.

PMID: 34960755 2021 Viruses

Result: A further reduction in neutralization titers was seen against pseudoviruses bearing both L452R and T478 substitutions in RBD displayed (GMT 192) compared to WT(D614G) (GMT 392).

Result: A modest 1.8-fold reduction in titers against C.37 pseudoviruses was observed compared to WT(D614G) pseudoviruses (GMT titers 222 and 392, respectively).

Result: A prior study showed that convalescent sera and vaccine-elicited antibody neutralization titers against pseudoviruses bearing spikes containing L452R-E484Q-P681R substitutions displayed 2-5-fold reduction, compared to the neutralization titers against WT(D614G) pseudoviruses.

Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment.

PMID: 32357545 2020 Pathogens (Basel, Switzerland)

Conclusion: The highly prevalent 23403A>G (p.D614G) variant in the European population ma

Discussion: A recent report corroborated our findings of high prevalence of D614G in Europe.

Discussion: However, given the small sample size, it is hard to ascertain whether D614G is the dominant strain in these countries.

A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?

PMID: 32422894 2020 Vaccines

Abstract: These two subtypes were divided by a novel synonymous mutation of D614G.

Introduction: If the mutation of D614G plays a crucial role in the positive selection process, SARS-CoV-2b will be the dominant type of SARS-CoV-2 in the future.

Introduction: Since no amino acid changes were found in this area other than the change of D614G, it is believed that this amino acid change alters the conformation of these immunogenic determinants; consequently, this region is expected to no longer act as a B-cell epitope in SARS-CoV-2b.

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.

PMID: 32451533 2020 American journal of clinical pathology

Table: D614G

COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.

PMID: 32464271 2020 International journal of infectious diseases

Introduction: For example, a substantial number of strains with the S-D614G variant are from the countries Belgium, Spain, Italy, France, Netherlands, and Switzerland that top the death toll (Figure 1B) (https://www.worldometers.info/coronavirus/; last accessed May 2, 2020); while Germany and Kuwait, with a lower death toll, constitute most strains with the wild-type 614D at S (Figure 1B).

Introduction: Overall, our observation speculates that the S-D614G strains may be more

Figure: The mutation observed at the S protein of the SARS-COV-2, D614G in white color, may create conformational changes mimicking the open status and facilitate the cleavage domain's exposure to proteases FURIN or TMPRSS2 and could be sufficient to speed up the cleavage.

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