Introduction: Although there is no evidence from available epidemiological and clinical data that the mutation of S protein D614G leads to increased pathogenicity or virulence of the virus, whether the transmission of the virus is enhanced still needs to be examined by systematic global assessment.
Introduction: Finally, we also need to note whether the epidemic of D614G mutant SARS-CoV-2 is random or naturally selected, as the virus is circulating globally at present.
Introduction: In a recent study, researchers found that a D614G mutation in the SARS-CoV-2 genome enhances the virus's ability to infect human
Figure: nt23403(A G) is a nonsynonymous substitution in S gene, which leads to D614G mutation of S protein (indicated in red).
BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.
PMID: 32904401
2020
Sustainable cities and society
Introduction: Recently, 7 substitution hotspots in SARS-CoV-2, ORF1ab-G10818T (ORF1ab-L3606F), ORF1ab-C8517T, ORF3a-G752T (ORF3a-G251V) S-A1841G (D614G), G171T (Q57H), ORF8-T251C (ORF8-L84S) and N-GGG608_609_610AAC (N-RG203_204KR) have been reported.
Table: D614G
Discussion: The latest study has discovered the strain with substitution of S-D614G could increases the infectivity of SARS-CoV-2.
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Introduction: Given that POC antibody tests were designed to detect antibodies to the wild-type S protein, we also aimed to investigate whether SARS-CoV-2 infections with D614G
Discussion: Demonstration that POC antibody LFA tests can detect the D614G spike mutant is therefore of importance.
Discussion: Of critical importance is the fact that both POC antibody tests (and ELISA) were able to detect antibody responses in patients infected with the D614G Spike mutant and that the band intensity of POC testing increased with neutralization activity in these individuals.
Discussion: The D614G Spike mutant has spread globally.
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
Abstract: Mutation D614G in the spike (S) protein has become dominant, and recent evidence suggests it yields a more stable phenotype with higher transmission efficacy.
Abstract: The D614G substitution creates a sticky packing defect in subunit S1, promoting its association with subunit S2 as a means to stabilize the structure of S1 within the S1/S2 complex.
Introduction: A biophysical/structural analysis of the impact of the D614G
Discussion: The structural, or rather epistructural, impact of the mutation D614G is consistent with established phenotypic differences between SG614 and SD614 in the sense that SG614 has a greater stability resulting from less S1 shedding and greater incorporation of the intact S protein into the pseudovirion.
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike.
Introduction: 5a), suggesting the D614G epitope was not a major antigenic site.
Introduction: SARS-CoV-2 has acquired a D614G mutation within the spike protein and viruses carrying this mutation have since become the dominant circulating strain globally as of early April.
Introduction: These data indicate that the region that encompasses the D614G mutation is not immunodominant or does not affect the antigenicity of epitopes at or near this site.
Introduction: We did not observe a difference in antibody titers against the WT and D614G spike antigens within our acute cohort.
Method: D614G spike protein, SARS-CoV-1 RBD, and MERS-CoV PMID: 32935498
2020
Zoological research
Abstract: Moreover, earlier claims that the D614G mutation is associated to higher transmissibility is not consistent with the very high prevalence of COVID-19 in Spain when compared to other countries with lower disease incidence but much higher frequency of this mutation (56.4% in Spain vs.
Result: Mutation D614G in Spain.
Result: Recen
Discussion: In fact, the low frequency of this mutation in Spain is difficult to reconcile with the high incidence of the disease in the country, compared to other countries with lower disease incidence but a higher frequency of D614G.
Discussion: We found no evidence to support previous claims suggesting increased transmissibility of SARS-CoV-2 strains carrying the amino-acid mutation D614G (basically all A2 haplotypes; see phylogeny of Figure 1 and).
Spatio-Temporal Mutational Profile Appearances of Swedish SARS-CoV-2 during the Early Pandemic.
8Discussion: The D614G mutant strain is designated as the ""G clade"" by GISAID and originated in Europe, and further spread to North America and Oceania, then Asia."
Discussion: A23403G is one of the most prominent mutations; it occurs in the S protein at amino acid residue 614, where Aspartic acid is substituted by Glycine (D614G).
Discussion: In Sweden, we found that on 14 May, the frequency of D614G on the S1 protein was 94.8% in the population.
Discussion: We saw this co-occurrence of D614G
Discussion: found that the D614G/ D936Y co-occur on the S1/S2 protein, and their emergence was traced back to 15 March in Washington, USA, and later on spread to Wales, Iceland, and the Netherlands.
Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization.
Abstract: Through ISM compression, we find that certain distant nucleotide variants covary, including non-coding and
Result: Some studies suggest that this D614G variant of the S spike protein provides greater survival and transmission ability to the virus, however there need to be additional studies conducted to confirm these claims.
Result: Subtypes including the A23403G/D614G spike protein variant.
Result: The SNV A23403G (resulting in D614G variant in spike protein) is a major viral mutation that has been observed in the major European countries of Italy, Spain, France, as well as Middle Eastern regions of Turkey and Israel.
Impact of Circulating SARS-CoV-2 Mutant G614 on the COVID-19 Pandemic.
PMID: 32943587
2020
Iranian journal of kidney diseases
Abstract: A SARS-CoV-2 variant encoding a D614G mutation in the viral spike (S) protein has now become the most prevalent form of the virus worldwide, suggesting a fitness advantage for the mutant.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Biosafety and health
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