Abstract: Emergence of a new variant of spike protein (D614G) with increased infectivity and transmissibility has prompted many to analyze the potential role of this variant in the SARS-CoV-2 pandemic.
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Abstract: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic.
Introduction: By early April 2020, it was clear that the Spike D614G mutation exhibited this behavior, and G614 has since become the dominant form in the pandemic.
Result: A comparison of D614G status and hospitalization (combining IP and ICU) was not significant (p = 0.66, Fisher's exact test), although comparing ICU admission with IP and OP did have borderline significance (p = 0.047) (Figure 5B).
Result: A generalized linear model (GLM) used to predict the PCR Ct based on the RT-PCR method, sex, age, and D614G status showed only the RT-PCR method (p < 2e-16) and D614G status (p = 0.037)
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear.
Abstract: Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.
Abstract: found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world.
Introduction: Although the D614G mutation is located in the virus's external spike protein that receives a lot of attention from the human immune system, and thus could have an influence on the ability of SARS-CoV-2 to evade vaccine-induced immunity, we think that it's unlikely for these reasons.
Introduction: And because of that, many questions remain on the potential impacts, if any, that D614G has on the COVID-19
SARS-CoV-2 genomic variations associated with mortality rate of COVID-19.
Result: Similarly, the frequency of a G variant of S protein D614G was significantly lower in the cluster 1 than the other two clusters (P = 1.2 x 10-6 and P = 1.7 x 10-5, respectively, for the clusters 2 and 3; Supplementary.
Result: We finally searched peptide epitopes with a high binding affinity to HLA molecules, which we previously reported, involving the two SARS-CoV-2 mutations, ORF1ab P4715L and S D614G, to investigate the association with host immune responses.
Result: We found that several epitopes, which include the position of ORF1ab P4715L or S protein D614G, are possibly bind to HLA molecules, incl
Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.
Abstract: Furthermore, 5A6 is insensitive to several spike mutations identified in clinical isolates, including the D614G mutant that has become dominant worldwide.
Result: 4c), including the D614G mutation that has spread at an alarming rate and become the dominant pandemic strain with a global frequency of 70.5% (GISAID), since its first identification in Europe in March.
Result: 8b), but its neutralizing potency against the D614G mutant was partially reduced.
3Introduction: Zu vorherrschenden Linien entwickelten sich dabei solche SARS-CoV-2-Viren, die auf den prominent aus dem Virus herausragenden ,,S spikes"" die Mutation D614G tragen."
Abstract: The D614G mutation in the S spikes seems to cause a higher infectiosity.
Introduction: Fur D614G wird aktuell keine Auswirkung auf Diagnostik, Impfstoff- oder DAA-Wirksamkeit befurchtet.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
Abstract: D614G, along with several variants containing both D614G and another amino acid change, were significantly more infectious.
Introduction: Preliminary study suggested that the increased fatality rate may be associated with the most dominant variant D614G.
Discussion: An amino acid change (D614G) outside the RBD was found to be more infectious, but no evidence of being resistant to neutralizing antibodies has been demonstrated.
Discussion: However, the increasing dominance of D614G particularly deserves attention.
Discussion: It is worth mentioning that D614G+I472V has shown increased infectivity and more resistance to neutralizing antibodies (Table 1), but only one sequence (o
Variant analysis of SARS-CoV-2 genomes.
PMID: 32742035
2020
Bulletin of the World Health Organization
Result: Most samples in the D614G clade also display the non-coding variant 241C > T, the synonymous variant 3037C > T and ORF1ab P4715L.
Result: The largest clade is D614G clade with five subclades.
Result: The recurrent stop-gained variant Y4379* (NSP10 Y126*) is found in 51 samples in the D614G clade.
Result: Within D614G clade, D614G/Q57H/T265I subclade forms the largest subclade with 2391 samples.
Discussion: Almost all strains with D614G mutation also have a mutation in the protein responsible
RdRp mutations are associated with SARS-CoV-2 genome evolution.
Result: A recent study postulated that one of the co-mutations of 14408C>T, namely 23403A>G that causes D614G mutation in the S protein, may result in a more transmissible form of SARS-CoV-2.
Result: A study by suggested that D614G mutation creates an additional protease cleavage site near the S1-S2 junction, which may increase the success of viral integration with the host cell, and linked its dominance in Europe to certain human variants that control expression of TMPRSS2.
Result: This claim was based mainly on the observation that D614G mutant virus became the dominant form in more than one geographical location upon its introduction, as summarized above for its co-mutation 14408C>T.
Result: Three other mutations that co-e
The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner.
Result: The D614G mutation on the Spike protein is located at the C-terminus of the S1 fragment and outside of the receptor-binding domain, and thus is unlikely to directly influence ACE2 binding.
Result: We did not observe any significant localization differences between Spike WT and Spike D614G in transiently transfected cells.
Result: With the human ACE2 however, we observed an 11% enhancement of D614G GFP+ cell depletion compared to WT Spike, which although small in magnitude achieved statistical significance (p <0.02) (Figure 1F).
Discussion: Given the location of the 614 residue within the S1 fragment distal to the RBD, it is also unlikely that the D614G
SARS_CoV_2 mutation literature information.
PMID: 
2020
medRxiv
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