Result: Of these, n = 79 (57%) carried the S protein D614G SNV, a mutation implicated in higher pathogenicity of the virus.
Result: Samples carrying the D614G SNV had higher SARS-CoV-2 genome loads as measured by CDC N3-primer directed real-time qRT-PCR for SARS-CoV-2 (p <= 0.002 by Wilcoxon signed rank test).
Discussion: Given the increasing abundance of D614G SNVs, further research into its role in pathogenicity and clinical outcomes is warranted.
Discussion: Multiple studies demonstrated superior infectivity of D614G-containing viruses or pseudotyped particles.
Discussion: Of the 87 sequences that have the D614G mutation, 69 have the C214T mutation, 15 have the C3037T mutation, and 4
Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal.
Introduction: A variant carrying the Spike D614G mutation stands out as a remarkable example, as it became dominant worldwide during the first months of the pandemic with recent studies suggesting that the G614 variant might be linked to an increased transmissibility but not pathogenicity.
Introduction: After the globally dispersed Spike D614G mutation, this is the first study reporting the superspread of a Spike variant with a tremendous epidemiological impact at country level.
Result: Most viruses (89.8%) integrate the phylogenetic branch enrolling clades 20A (40.8%), 20B (46.1%) and 20C (2.9%), carrying, among other genetic markers, the D614G amino acid replacement in the Spike protein.
3Introduction: Zu vorherrschenden Linien entwickelten sich dabei solche SARS-CoV-2-Viren, die auf den prominent aus dem Virus herausragenden ,,S spikes"" die Mutation D614G tragen."
Abstract: The D614G mutation in the S spikes seems to cause a higher infectiosity.
Introduction: Fur D614G wird aktuell keine Auswirkung auf Diagnostik, Impfstoff- oder DAA-Wirksamkeit befurchtet.
SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility.
Abstract: During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein emerged and became the predominant circulating variant (S-614G) of the COVID-19 pandemic 1 .
Introduction: S-D614G is a protein variant containing a substitution in the S protein outside of the RBD and is thought to cause a conformational change.
Introduction: The data show that the S-D614G substitution confers increased binding to the hACE2 receptor and increased replication in primary human airway epithelial cultures.
Abstract: The D614G mutation in the S spikes seems to cause a higher infectiousness.
Introduction: Fur D614G wird aktuell keine Auswirkung auf Diagnostik, Impfstoff- oder DAA-Wirksamkeit befurchtet.
Introduction: Zur vorherrschenden Linie entwickelten sich dabei solche SARS-CoV-2-Viren, die auf den prominent aus dem Virus herausragenden S-Spikes die Mutation D614G tragen.
New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release.
Abstract: Mutation entropy decreased between March and April of 2020 after steady increases at several sites, including the D614G mutation site of the spike (S) protein that was previously found associated with higher case fatality rates and at sites of the NSP12 polymerase and the NSP13 helicase proteins.
Discussion: (1) S-protein: As previously reported, our research exploration reveals the active fixation of the D614G mutation of the S-protein of the spike, which we also find has coordinated entropic trends associated with the P323L mutation of the NSP12
SARS-CoV-2 spread across the Colombian-Venezuelan border.
PMID: 33157300
2020
Infection, genetics and evolution
8Discussion: Additionally, the presence of substitution D614G in the spike protein of the three viruses from patients residing in the current hotspots of COVID-19 in Venezuela may correlate with the reported increased infectivity observed in SARS-CoV-2-infected patients in the state of Zulia ("""")."
Abstract: We observed a point mutation in the Spike protein gene (D614G substitution), previously reported to be associated with increased infectivity, in all three Venezuelan genomes.
Result: The three Venezuelan genomes carried a G-to-A point mutation at position 23,403 resulting in a D614G substitution in the spike (S) protein.
The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene.
5Result: aspartic acid 614 codon ""GAT"" (reference sequence) was substituted by glycine 614 codon ""GGT"" (D614G) by chromatographic DNA sequencing result."
Result: DNA sequencing of the S gene cDNA revealed three mutations in addition to the known D614G mutation.
Result: Interestingly, the known mutation site D614G residue including three novel mutation sites are conserved between severe acute respiratory syndrome (SARS) and SARS-CoV2 in.
Result: The alignment of four SARS-CoV2 spike amino acid sequences compared to the wild type sequence revealed that there are two additional mutations in the critical RBD and another mutation in subdomain (SD) 2, which is very close to the known mutation residue D614G.
Result: The known
Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh.
Abstract: Genome-wide annotations revealed 256 mutations, of which 10 were novel (NSP3, RdRp, Spike) in Bangladeshi strains where I120F(NSP2), P323L(RdRp), D614G (Spike), R203K, G204R(N) are the most prominent.
Discussion: Among the mutations, the most frequent 2 mutations were D614G (Spike protein) and P323L (NSP12).
Discussion: in 2020 suggested that heavy alteration in the glycosylated PMID: 33166683
2020
Infection, genetics and evolution
Discu
Discussion: D614G mutants began expanding in Europe and rapidly became dominant species.
Discussion: All of the evaluated samples in their report have been isolated in the first three months of 2020, while our first D614G mutant isolated in June.
Discussion: Regarding this and also the importance of D614G in comparison to other mutations, here we evaluated the rapid and inexpensive PCR-RFLP method for the detection of this mutation.
Discussion: The D614G mutation was first identified in Germany.
Discussion: reported the D614G mutation in Taiwanese patients and patients who had a history of travel to Europe, Turkey, and Iran.
Discussion: reported the viral genome sequences to include D614G mutation in the travelers who returned from Iran.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Cell reports
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