Abstract: Mutation D614G in the spike (S) protein has become dominant, and recent evidence suggests it yields a more stable phenotype with higher transmission efficacy.
Abstract: The D614G substitution creates a sticky packing defect in subunit S1, promoting its association with subunit S2 as a means to stabilize the structure of S1 within the S1/S2 complex.
Introduction: A biophysical/structural analysis of the impact of the D614G
Discussion: The structural, or rather epistructural, impact of the mutation D614G is consistent with established phenotypic differences between SG614 and SD614 in the sense that SG614 has a greater stability resulting from less S1 shedding and greater incorporation of the intact S protein into the pseudovirion.
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike.
Introduction: 5a), suggesting the D614G epitope was not a major antigenic site.
Introduction: SARS-CoV-2 has acquired a D614G mutation within the spike protein and viruses carrying this mutation have since become the dominant circulating strain globally as of early April.
Introduction: These data indicate that the region that encompasses the D614G mutation is not immunodominant or does not affect the antigenicity of epitopes at or near this site.
Introduction: We did not observe a difference in antibody titers against the WT and D614G spike antigens within our acute cohort.
Method: D614G spike protein, SARS-CoV-1 RBD, and MERS-CoV PMID: 32935498
2020
Zoological research
Abstract: Moreover, earlier claims that the D614G mutation is associated to higher transmissibility is not consistent with the very high prevalence of COVID-19 in Spain when compared to other countries with lower disease incidence but much higher frequency of this mutation (56.4% in Spain vs.
Result: Mutation D614G in Spain.
Result: Recen
Discussion: In fact, the low frequency of this mutation in Spain is difficult to reconcile with the high incidence of the disease in the country, compared to other countries with lower disease incidence but a higher frequency of D614G.
Discussion: We found no evidence to support previous claims suggesting increased transmissibility of SARS-CoV-2 strains carrying the amino-acid mutation D614G (basically all A2 haplotypes; see phylogeny of Figure 1 and).
Spatio-Temporal Mutational Profile Appearances of Swedish SARS-CoV-2 during the Early Pandemic.
8Discussion: The D614G mutant strain is designated as the ""G clade"" by GISAID and originated in Europe, and further spread to North America and Oceania, then Asia."
Discussion: A23403G is one of the most prominent mutations; it occurs in the S protein at amino acid residue 614, where Aspartic acid is substituted by Glycine (D614G).
Discussion: In Sweden, we found that on 14 May, the frequency of D614G on the S1 protein was 94.8% in the population.
Discussion: We saw this co-occurrence of D614G
Discussion: found that the D614G/ D936Y co-occur on the S1/S2 protein, and their emergence was traced back to 15 March in Washington, USA, and later on spread to Wales, Iceland, and the Netherlands.
Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization.
Abstract: Through ISM compression, we find that certain distant nucleotide variants covary, including non-coding and
Result: Some studies suggest that this D614G variant of the S spike protein provides greater survival and transmission ability to the virus, however there need to be additional studies conducted to confirm these claims.
Result: Subtypes including the A23403G/D614G spike protein variant.
Result: The SNV A23403G (resulting in D614G variant in spike protein) is a major viral mutation that has been observed in the major European countries of Italy, Spain, France, as well as Middle Eastern regions of Turkey and Israel.
Impact of Circulating SARS-CoV-2 Mutant G614 on the COVID-19 Pandemic.
PMID: 32943587
2020
Iranian journal of kidney diseases
Abstract: A SARS-CoV-2 variant encoding a D614G mutation in the viral spike (S) protein has now become the most prevalent form of the virus worldwide, suggesting a fitness advantage for the mutant.
Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America.
PMID: 32950697
2020
Infection, genetics and evolution
Abstract: The substitutions D614G in S and R203K/G204R in N were the most frequent in South America, observed in 83% and 34% of the sequences respectively.
Conclusion: Amino acid changes were found in the S and N proteins of SARS-CoV-2 circulating in South America, the most frequent being D614G in S and R203K-G204R and I292T in N.
Result: The
Figure: Spatiotemporal distribution of the D614G substitution in the Spike protein of SARS-CoV-2 in South America.
A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual.
PMID: 32967693
2020
Journal of translational medicine
Result: Alignment analyses showed that, with respect to the Wuhan-Hu-1 Reference Genome NC_045512.2, SARS-CoV-UNIBS-2 AP66 consensus sequence displayed 6 nucleotide substitutions (C241T; C3037T; C14408T; T21784G; C21846T; A23403G) leading to 4 non-synonymous changes (ORF1ab polypeptide: P4715L; S protein: N74K, T95I, D614G).
Result: Less pathogenic GZ69 consensus sequence differed from Wuhan-Hu-1 isolate in 11 nucleotide positions (C241T; C2939T; C3037T
Coding-Complete Genome Sequences of Three SARS-CoV-2 Strains from Bangladesh.
Introduction: Compared with hCoV-19/Wuhan/WIV04/2019, for strain BCSIR-NILMRC-006, we found eight mutations, including NSP2_G339S, N_R203K, N_G204R, NSP3_Q172R, Spike_D614G, NSP2_I120F, NSP12_P323L, and NSP2_V480I.
Introduction: In BCSIR-NILMRC-008, the genome mutations Spike_D614G, N_R203K, N_G204R
Table: D614G
Whole-Genome Sequence of SARS-CoV-2 Isolate Siena-1/2020.
Abstract: The isolate belongs to the B1.1 lineage, which is prevalent in Europe, and contains a mutation in the spike protein coding sequence leading to the D614G amino acid change.
Introduction: Among the 5 single nucleotide changes, the one at position 23403 causes a change in the predicted amino acid sequence of the spike (S) protein (D614G), which is now the most common variant worldwide.
SARS_CoV_2 mutation literature information.
PMID: 
2020
ACS medicinal chemistry letters
Browser Board
Co-occurred Entities
Filtrator
ViMRT