Abstract: We find limited diversity across SARS-CoV-2 genomes: Only 11 sites show polymorphisms in >5% of sequences; yet two mutations, including the D614G mutation in Spike, have already become consensus.
Abstract: While the rapid spread of the D614G mutation warrants further study, our results indicate that drift and bottleneck events can explain the minimal diversity found among SARS-CoV-2 sequences.
Discussion: A mutation, S612L, that emerged in MERS-CoV after passaging the virus in the presence of two antibodies (in 5/15 clones after 20 passages) warrants the evaluation of the analogous D614G mutation in SARS-CoV-2 for its ability to interfere with the recognition of a distal epitope.
Discussion: As such, on January 28, 2020, a virus carrying the D614G mutation,
SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution.
Result: Four genetically linked mutations previously described as the globally dominant haplotype in April 2020 were found in the majority of our consensus sequences: C241T (100%; 5'UTR region), C3037T (98.6%; silent mutation), C14408T (100%; resulting in P4715L/P323L amino acid change in ORF1ab) and A23403G (100%; resulting in D614G amino acid change in S).
Discussion: As expected, the P323L change in the RNA-dependent RNA polymerase (RdRp), genetically linked to D614G, was also found
Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.
Result: 20A is a derivative of 19A and contains mutations C3037T, C14408T and A23403G (resulting in D614G).
Result: A total of 173 cases were analyzed to determine the number and relative proportion of the specimens which carried the Discussion: It is possible that these measures, compounded by potential inherent transmission variability of some viral isolates, influenced the change in the frequency of D614G, clades and P323L/F that we noted during this time period within Nevada.
Discussion: We find that the overall trend for D614G in Nevada during this time period was similar to what was observed in other states and internationally, with the exception of within Asia where the D614 allele had originated.
Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences.
Abstract: A virus mutation (D614G) may cause differing infectivity, while at the host level genetic, ethnicity-specific variants of the virus-binding entry proteins may facilitate virus entry in the olfactory epithelium and taste buds.
Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp.
Introduction: Claims of increased transmissibility of this new strain due to spike D614G mutation by were met with caution, as other factors such as founder effect, drift etc.
Introduction: However, animal studies will be required to further test the effects of the D614G mutation to reach a more definitive conclusion.
Introduction: Our previous study suggested that RdRp 14408 C>T mutation is associated with SARS-CoV-2 genome evolution and could even be working synergistically with the 23403 A>G (D614G) mutation.
Introduction: Soon after its spread to Europe and the US, a strain of SARS-CoV-2 with two non-synonymous mutations in the RNA-dependent RNA polymerase (
Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development.
PMID: 32884216
2020
Journal of laboratory physicians
Table: D614G
Figure: Two Major clades A and B are formed due to the most prevalent mutations D614G.
Discussion: Out of 88 SNP clusters, D614G was found in 34 (38.6%) SARS-CoV-2 genomes.
Discussion: The amino acid change in 23403A>G variant (p.D614G) involves a change of large acidic residue D (aspartic acid) into small hydrophobic residue G (glycine).
Genomic characterization of SARS-CoV-2 identified in a reemerging COVID-19 outbreak in Beijing's Xinfadi market in 2020.
Introduction: Although there is no evidence from available epidemiological and clinical data that the mutation of S protein D614G leads to increased pathogenicity or virulence of the virus, whether the transmission of the virus is enhanced still needs to be examined by systematic global assessment.
Introduction: Finally, we also need to note whether the epidemic of D614G mutant SARS-CoV-2 is random or naturally selected, as the virus is circulating globally at present.
Introduction: In a recent study, researchers found that a D614G mutation in the SARS-CoV-2 genome enhances the virus's ability to infect human
Figure: nt23403(A G) is a nonsynonymous substitution in S gene, which leads to D614G mutation of S protein (indicated in red).
BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.
PMID: 32904401
2020
Sustainable cities and society
Introduction: Recently, 7 substitution hotspots in SARS-CoV-2, ORF1ab-G10818T (ORF1ab-L3606F), ORF1ab-C8517T, ORF3a-G752T (ORF3a-G251V) S-A1841G (D614G), G171T (Q57H), ORF8-T251C (ORF8-L84S) and N-GGG608_609_610AAC (N-RG203_204KR) have been reported.
Table: D614G
Discussion: The latest study has discovered the strain with substitution of S-D614G could increases the infectivity of SARS-CoV-2.
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Introduction: Given that POC antibody tests were designed to detect antibodies to the wild-type S protein, we also aimed to investigate whether SARS-CoV-2 infections with D614G
Discussion: Demonstration that POC antibody LFA tests can detect the D614G spike mutant is therefore of importance.
Discussion: Of critical importance is the fact that both POC antibody tests (and ELISA) were able to detect antibody responses in patients infected with the D614G Spike mutant and that the band intensity of POC testing increased with neutralization activity in these individuals.
Discussion: The D614G Spike mutant has spread globally.
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Proc Natl Acad Sci U S A
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