3Introduction: Zu vorherrschenden Linien entwickelten sich dabei solche SARS-CoV-2-Viren, die auf den prominent aus dem Virus herausragenden ,,S spikes"" die Mutation D614G tragen."
Abstract: The D614G mutation in the S spikes seems to cause a higher infectiosity.
Introduction: Fur D614G wird aktuell keine Auswirkung auf Diagnostik, Impfstoff- oder DAA-Wirksamkeit befurchtet.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
Abstract: During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein emerged and became the predominant circulating variant (S-614G) of the COVID-19 pandemic 1 .
Introduction: S-D614G is a protein variant containing a substitution in the S protein outside of the RBD and is thought to cause a conformational change.
Introduction: The data show that the S-D614G substitution confers increased binding to the hACE2 receptor and increased replication in primary human airway epithelial cultures.
Abstract: The D614G mutation in the S spikes seems to cause a higher infectiousness.
Introduction: Fur D614G wird aktuell keine Auswirkung auf Diagnostik, Impfstoff- oder DAA-Wirksamkeit befurchtet.
Introduction: Zur vorherrschenden Linie entwickelten sich dabei solche SARS-CoV-2-Viren, die auf den prominent aus dem Virus herausragenden S-Spikes die Mutation D614G tragen.
New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release.
Abstract: Mutation entropy decreased between March and April of 2020 after steady increases at several sites, including the D614G mutation site of the spike (S) protein that was previously found associated with higher case fatality rates and at sites of the NSP12 polymerase and the NSP13 helicase proteins.
Discussion: (1) S-protein: As previously reported, our research exploration reveals the active fixation of the D614G mutation of the S-protein of the spike, which we also find has coordinated entropic trends associated with the P323L mutation of the NSP12
SARS-CoV-2 spread across the Colombian-Venezuelan border.
PMID: 33157300
2020
Infection, genetics and evolution
8Discussion: Additionally, the presence of substitution D614G in the spike protein of the three viruses from patients residing in the current hotspots of COVID-19 in Venezuela may correlate with the reported increased infectivity observed in SARS-CoV-2-infected patients in the state of Zulia ("""")."
Abstract: We observed a point mutation in the Spike protein gene (D614G substitution), previously reported to be associated with increased infectivity, in all three Venezuelan genomes.
Result: The three Venezuelan genomes carried a G-to-A point mutation at position 23,403 resulting in a D614G substitution in the spike (S) protein.
The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene.
5Result: aspartic acid 614 codon ""GAT"" (reference sequence) was substituted by glycine 614 codon ""GGT"" (D614G) by chromatographic DNA sequencing result."
Result: DNA sequencing of the S gene cDNA revealed three mutations in addition to the known D614G mutation.
Result: Interestingly, the known mutation site D614G residue including three novel mutation sites are conserved between severe acute respiratory syndrome (SARS) and SARS-CoV2 in.
Result: The alignment of four SARS-CoV2 spike amino acid sequences compared to the wild type sequence revealed that there are two additional mutations in the critical RBD and another mutation in subdomain (SD) 2, which is very close to the known mutation residue D614G.
Result: The known
Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh.
Abstract: Genome-wide annotations revealed 256 mutations, of which 10 were novel (NSP3, RdRp, Spike) in Bangladeshi strains where I120F( Discussion: Among the mutations, the most frequent 2 mutations were D614G (Spike protein) and P323L (NSP12).
Discussion: Moreover, D614G substitution may affect the structure of spike glycoprotein which helps the virus to enter into the host cell by binding to the ACE2 receptor.
Discussion: in 2020 suggested that heavy alteration in the glycosylated spike protein might be resulted due to the D614G mutation.
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
PMID: 33166683
2020
Infection, genetics and evolution
Abstract: Regarding the high price and low availability of sequencing techniques in developing countries, here we describe a rapid and inexpensive method for the detection of D614G mutation in SARS-CoV-2.
Abstract: Using bioinformatics databases and software, we designed the PCR-RFLP method for D614G mutation detection.
Abstract: We have little information about the prevalence of D614G mutation, and it seems that the reason is the lack of cheap and fast methods.
Abstract: We hope that this method will provide more information on the prevalence and epidemiology of D614G mutations worldwide.
Introduction: From the beginning of the COVID-19 epidemic, many articles published on the evaluation of D614G mutation in SARS-CoV-2.
Introduction: Given t
Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.
Result: However, cluster harboring D614G (in spike), F924F (in orf1ab), and L4715L (in orf1ab) mutations, showed no correlation and were scatted through all countries especially those from Europe.
Result: Strains from the second clad C2 shared the spike mutation D614G (S) and harbored three subclades, this clade started in shanghai end of Jan.
Result: Th
Result: The most represented was D614G mutation at spike protein with 43.46% (n = 1.333) of the genomes, the second was L84S (at ORF8) found in 23.21% (n = 712).
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
Result: Among the TTG signature SNVs, C14408T (nsp12, P4715L) is located in the RdRp gene that plays a role in replication, and A23403G (S protein, D614G) impacts the S protein that plays a role in receptor binding, membrane fusion, and virus entry.
Discussion: In addition, the strong allelic association among the long-distant variations C3037T (nsp3, F924F), C14408T (RdRp, P4715L), A23403G (
SARS_CoV_2 mutation literature information.
PMID: 
2020
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