Abstract: However, the D614G variant transmits significantly faster and displayed increased competitive fitness than the wild-type virus in hamsters.
Abstract: The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear.
Abstract: These data show that the D614G substitution enhances SARS-CoV-2 infectivity, competitive fitness, and transmission in primary human cells and animal models.
Introduction: After three continuous passages at 72h intervals, the D614G variant became dominant in the cultures regardless of whether the WT virus was at a 1:1 or 10:1 ratio
Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment.
Abstract: A recent study reported that the D614G mutation in the SARS-CoV-2 virus spike protein reduces S1 shedding and increases infectivity of SARS COV-2 virus.
Introduction: It was reported that the D614G mutation reduces S1 shedding and increases infectivity.
Copper(II) Inhibition of the SARS-CoV-2 Main Protease.
Abstract: We also started studying the Spike Protein, PDB ID: 6VXX and the region around the D614G mutant.
Introduction: We are testing the proposal that cobalt(III) or copper(II) binding to these residues would partially unfold the protein, including the region around GLY 614 in the D614G mutant.
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.
Abstract: The prevalence of the former reflected probable European origin of viruses, and the transition D614G was dominant in Vietnam.
Abstract: The three most common variants were linked, and included C3037T, C14408T (nsp12: P323L) and A23403G (S: D614G) mutations.
Discussion: Of the SARS-CoV-2 genomes from the first two patients in Vietnam (one from Wuhan who transmitted to a second case), the D614G change was not found.
Discussion: The
Discussion: The B.1 lineage and its sublineages have formed the majority of sequences from Vietnam since March 2020 (S1 Fig) and harbour D614G.
Loss of orf3b in the circulating SARS-CoV-2 strains.
Result: All H57 strains clustered within the clades with spike G614, indicating that this mutation has co-evolved with the D614G mutation (blue box in Figure 1A and coloured as blue in Figure 1C).
Result: Also, the Delta3b viruses contain both the orf3a Q57H substitution and D614G mutation.
Result: For instance, viruses with D614G mutation in Spike protein have acquired enhanced transmissibility and infectivity and become the dominant circulating strain.
Result: In our analysis, spike D614G substitution was also included as a reference since it signifies the evolutionary phases of SARS-CoV-2 (blue box in Figure 1A, and blue lines in Figure 1C).
Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19.
Abstract: In addition, the antibodies elicited were able to cross-neutralize pseudovirus containing the spike protein of the D614G variant, indicating the potential for broad spectrum protection.
Method: Site-directed mutagenesis was used to generate the D614G variant by changing nucleotide at position 23403 (Wuhan-Hu-1 reference strain) from A
Figure: Inhibition of pseudoviruses carrying D614D (wild-type) or D614G (variant) versions of the spike protein by mice immunized with S-2P with CpG 1018 and aluminum hydroxide.
Figure: Neutralization assays were performed with pseudoviruses with either D616D or D614G spike proteins.
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.
Introduction: At least two groups independently noted that D614G mutation correlated with increased viral loads in COVID-19 patients, but because this change is also associated with three or four other mutations in other viral proteins including nsp3 and
Table: D614G
Figure: The D614G mutation is associated with enhanced infectivity.
Figure: The D614G mutation neither increases S protein affinity for ACE2 nor makes PV more resistant to neutralization.
Figure: b A representation of the SARS-CoV-2 S protein (top) and D/G variation at residue 614 presented in logo plots at different time points between January 1st and May 30th, 2020 (bottom).
SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia.
Result: The mutation D614G in the spike protein, which may increase infectivity of SARS-CoV-2 and has become prevalent in many countries, was only observed in 13 (11.3%) Malaysian sequences from lineages B.1, B.1.1, B.1.1.1 and B.1.36 (S3 Table), but was not present in lineage B.6.
Origin, evolution and global spread of SARS-CoV-2.
Abstract: These are generally neutral and have no impact on virulence and severity, but some appear to influence infectivity, notably the D614G mutation of the Spike protein.
CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention.
Result: Although we identified major mutations on CD8 T cell epitopes including L5F, D614G and G1124V for the SARS-CoV-2 S protein, the detailed mechanisms driving these mutations are not known.
Result: Effect of D614G mutation on CD8 T cell epitope generation.
Result: In addition, these mutations are exclusively L to F at position 5, D to G at position 614 and G to V at position 1124.
Result: Similarly, we reanalyzed the 9-mer CD8 T cell epitope for the reference S protein with a single D614G mutation.
Result: These results illustrated differential effects of D614G mutation on the ca
SARS_CoV_2 mutation literature information.
PMID: 
2020
Science (New York, N.Y.)
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