literature

SARS_CoV_2 mutation literature information.

Design of SARS-CoV-2 Variant-Specific PCR Assays Considering Regional and Temporal Characteristics.

PMID: 35285246 2022 Applied and environmental microbiology

Result: As a result, for the Alpha variant, we identified nine mutations in the spike gene: S:Delta69/70, S:Delta144, S:N510Y, S:A570D, S:D614G, S:P681H, S:T716I, S:S982A, and S:D1118H.

Result: For the Delta variant, we identified seven mutations: S:T19R, S:Delta156/157, S<

Tracking SARS-CoV-2 variants by entire S-gene analysis using long-range RT-PCR and Sanger sequencing.

PMID: 35304093 2022 Clinica chimica acta; international journal of clinical chemistry

5Result: Samples that could not determine the lineage of SARS-CoV-2 because of the lack of specific mutation patterns except for S:D614G were classified as ""Undetermined."" To assess the dynamic of circulating SARS-CoV-2, we compared our data with the reported lineages in Chiba University Hospital."

Abstract: RESULTS: The S:D614G mutation was found in all samples.

Result: All of the sequenced samples had S:D614G mutation.

Identification of a novel SARS-CoV-2 variant with a truncated protein in ORF8 gene by next generation sequencing.

PMID: 35301412 2022 Scientific reports

Abstract: This variant belongs to Pango lineage B.1.1291, which also contains the D614G mutation in the Spike (S) gene.

Table: D614G

SARS-CoV-2 spike E156G/Delta157-158 mutations contribute to increased infectivity and immune escape.

PMID: 35296517 2022 Life science alliance

Abstract: We confirmed the presence of E156G/Delta157-158 from cases concurrently screened, in addition to other circulating spike (S1) mutations such as T19R, T95I, L452R, E484Q, and D614G.

Figure: The affinity for the ACE2 receptor was normalized to the D614G-pseudotyped lentiviral particles.

Figure: The fold difference in response to the neutralizing plasma was measured compared to the reference D614G mutant spike

RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant.

PMID: 35293849 2022 Emerging microbes & infections

Introduction: Delta variants have a number of characteristic mutations in their spike protein, including single-nucleotide polymorphisms (SNPs) resulting in T19R, R158G, L452R, T478 K, D614G, P681R, and D950N, which are usually chosen as the detection targets of the molecular diagnostics for Delta genotyping.

Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivity.

PMID: 35293847 2022 Emerging microbes & infections

Introduction: L452R, E484Q, D614G, and P681R) are identical or similar to those in other globally circulating SARS-CoV-2 variants.

Introduction: Mutation sites involved in the B.1.617 sub-lineages include T19R, T95I, G142D, E154K, F157del, R158del, L452R, T478K, E484Q, D614G, P681R, D950N, Q1071H, and H1101D.

Introduction: The

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.

PMID: 35290827 2022 EBioMedicine

Method: The Result: As previously reported, the D614G and Alpha spike variants were less fusogenic than the Delta spike (Figure 2a, b, Figure S2).

Result: We previously reported using this assay that the spike protein of Alpha had the highest affinity to ACE2, followed by Delta and then by D614G.

Potential inhibitor for blocking binding between ACE2 and SARS-CoV-2 spike protein with mutations.

PMID: 35279013 2022 Biomedicine & pharmacotherapy

Discussion: Beta variant contains nine mutations in SARS-CoV-2 spike protein: D614G, Delta242-Delta244, R246I, K417N, E484K, N501Y, and A701V.

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model.

PMID: 35273335 2022 Communications biology

Introduction: Experimental data from human lung epithelium and animal models revealed that the D614G substitution increased virus infectivity and transmissibility as compared to an original D614 strain.

Introduction: From January 2020, viruses carrying the spike D614G mutation emerged in several countries.

Introduction: In June, D614G SARS-CoV-2 lineage B.1 became the dominant form of circulating virus worldwide and replaced the initial SARS-CoV-2 strains related to the outbreak in Wuhan, China.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: D614G in the RBM domain has shown to increase the S-protein density on the viral surface, thereby enhancing infectivity.

Introduction: And cilgavimab had lower activity against N501Y+D614G mutants, including B.1.429 (carrying L452R), B.1.617.2 (carrying L452R + T478K) and B.1.351 (carrying K417N + E484K + N501Y).

Introduction: Both P4715L and P323L was observed along with S protein D614G mutation, suggesting a co-evolutionary pattern.

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