Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2.
PMID: 34445414
2021
International journal of molecular sciences
Abstract: In this study, Korean mutants for spike protein (D614G and D614A-C terminal domain, L455F and F456L-RBD, and Q787H-S2 domain) were investigated in patients.
Introduction: Variants in the S protein, such as D614G, D614A, L455F, F456L, and Q787H, have been identified.
Method: Overall, 18 structures (the 1-, 2-, and 3-open-complex forms for the wild type, D614G, D614A, L455F, F456L
Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.
PMID: 34763050
2021
Infection, genetics and evolution
Result: The Gamma sequences generated herein presented the classical mutational signatures in spike glycoprotein L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G
Discussion: Besides those sequenced, 11 sequences presented the D614A mutation in GISAID, however, they belong to A.24 from Asia (6 sequences), B.1.1.7 from Europe (4 sequences) and B.1.2 from North American (1 sequence).
Discussion: The D614G for D614A change has already been identified in July 2020 in three individuals who returning to Korea from Uzbekistan .
CoV2-ID, a MIQE-compliant sub-20-min 5-plex RT-PCR assay targeting SARS-CoV-2 for the diagnosis of COVID-19.
Discussion: Nonetheless, a SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has replaced the original D614A variant in many locations.
SARS_CoV_2 mutation literature information.
PMID: 
2021
International journal of molecular sciences
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