Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.
PMID: 34121839
2021
Bioinformatics and biology insights
Table: D574Y
Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021.
Result: 5): mutation S98F is located next to amino acid 69, which is deleted in variant B.1.1.7; substitution D574Y maps next to amino acid 570, which changes from alanine (A) to aspartic acid (D) in B.1.1.7 viruses; and mutations T478A, F490S, and S494P locate in the RBD, near amino acid 501, which changes from asparagine (N) to tyrosine (Y) in B.1.1.7.
Table: D574Y
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Abstract: Vaccine breakthrough infections showed unique mutational changes at position S:D574Y in the case of the Delta variant, whereas position S:T95 was conserved among Kappa variants compared to the Wuhan isolate.
Conclusion: The breakthrough infections showed unique mutational changes at position S:D574Y<
Result: Interestingly, an exceptional aa change was detected at position D574Y in two cases, one from GR clade and one from Delta variant with breakthrough infection, whereas another breakthrough infection from the Kappa variant conserved the aa change at position 95 (T) as in the Wuhan isolate.
Result: The uncommon aa change D574Y was uniquely detected in two variants including GR clade (MCL-20-H-405) and Delta variant (MCL-21-6602).
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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