The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.
PMID: 33199022
2021
Biochemical and biophysical research communications
Introduction: However, antigenic drift is known to occur among the endemic human coronaviruses, and during the first SARS outbreak in 2003, a single amino acid mutation in SARS-CoV (D480 A/G) within the receptor binding domain (RBD) of the Spike (S) protein became the dominant variant due to its ability to escape from neutralising antibodies.
Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development.
Introduction: D480A/G variant has been shown to escape neutralizing antibody and immune pressure.
Introduction: In RBD of the spike protein, D480A/G mutation has emerged in patients with SARS-CoV infection and has become the dominant variant among 2003/2004 viruses.
Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.
Introduction: For example, the P462L and D480 A/G mutations that occur in SARS-CoV induce viruses to escape to a monoclonal NAb.
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Introduction: During the SARS epidemic in 2003, the single amino acid mutation D480A/G in the RBD domain of SARS-CoV spike protein gradually became dominant, and subsequent study confirmed that this mutation occurred in a critical site and enabled the mutant escaping neutralizing antibodies.
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Introduction: D480A/G escapes neutralizing antibody 80R, and immune pressure from 80R in vitro could recapitulate emergence of the D480 mutation.
Introduction: Notably, a single SARS-CoV-1 amino acid change, Spike D480A/G in the receptor binding domain (RBD), arose in infected humans and civets and became the dominant variant among 2003/2004 viruses.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Biochemical and biophysical research communications
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