Abstract: We identified an ACE2 SNP, D355N, that restricts the spike protein-ACE2 interaction and consequently has the potential to protect individuals against SARS-CoV-2 infection.
Abstract: We identified the ACE2 D355N variant that restricts the spike protein-ACE2 interaction and consequently limits infection both in vitro and in vivo.
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.
Abstract: While ACE2 mutants D355N, R357A, and R357T abrogated entry by both SARS-CoV and SARS-CoV-2 spike proteins, the Y41A mutant inhibited SARS-CoV entry much more than SARS-CoV-2, suggesting differential utilization of the ACE2 side-chains within the largely overlapping interaction surfaces utilized by the two CoV spike proteins.
Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.
PMID: 34720581
2021
Bioinformatics and biology insights
Result: We analyzed the effect of seven missense variants of ACE2 on the binding interaction of ACE2 with SARS-CoV-2 spike protein (RBD) and observed that E35K, E37K, M82I, E329G, and D355N variants of ACE2 have no significant alteration in binding interaction.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Journal of virology
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