Introduction: This lineage has increased rapidly and carries Spike mutations including: D253G reported as an antibody escape mutation against the N-terminal domain; D614G (in common with 20I/501Y.V1, 20H/501Y.V2, and 20J/501Y.V3); and A701V, in common with 20H/501Y.V2.
Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.
PMID: 34121839
2021
Bioinformatics and biology insights
Table: D253G
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: Although the B.1.526 NTD harbours with L5F, T95I, and D253G, three mutations which are distinct from B.1.429, the 3D model of B.1.526 spike predicts a similar structural rearrangement of loop N5 (245-264aa) (Figure 6d).
Introduction: This aberration may be linked with the D253G replacement in this loop.
Novel SARS-CoV-2 variants: the pandemics within the pandemic.
PMID: 34015535
2021
Clinical microbiology and infection
Method: The D253G mutation is also notable, and believed to play a role in immune escape.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Result: Among the nucleotide mutations in lineage B.1.526, the most characteristic include A16500C (NSP13 Q88H),
Result: We generated HIV-based pseudoviruses expressing SARS-CoV-2 spike protein containing either the most common B.1.526 mutation pattern (v.1: L5F, T95I, D253G, E484K, D614G, and A701V), the 2nd most common pattern (v.2: L5F, T95I, D253G, S477N, D614G, and Q957R), or only D614G.
Emergence and Expansion of the SARS-CoV-2 Variant B.1.526 Identified in New York.
Introduction: 2A) that initially lacked the L5F, D253G, and E484K mutations.
Introduction: 2B shows that D253G resides in the antigenic supersite within the N-terminal domain, which is a target for neutralizing antibodies, whereas the E484K is situated at the RBD interface with the cellular receptor ACE2.
Introduction: Nearly all of the newly identified B.1.526 variants have a set of common mutations in the spike protein: L5F, T95I, D253G, E484K, D614G, and A701V.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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