Conclusion: The non-synonymous SARS-CoV-2 SNV NSP3 D218E is inversely associated with the humoral response to S subunits 1 and 2.
Result: For higher anti-S2 IgG levels, the presence of NSP3 D218E was revealed as the only independent predictor, which is in strong contrast to anti-S1 IgG.
Result: The absence of the genetic SARS-CoV-2 variant NSP3 D218E was an additional independent predictor for higher anti-S1 IgG levels whereas the absence of chronic liver disease was one for higher anti-S/N IgG levels.
Table: D218E
Discussion: For the first time, we showed the positive association of higher anti-S2 IgG levels wit