literature

SARS_CoV_2 mutation literature information.

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1.

PMID: 35126886 2022 Computational and structural biotechnology journal

Result: The values for WT, D155Y and S171L were -37.64 (8.32) kcal/mol, -20.31 (8.60) kcal/mol and -28.39 (0.71) kcal/mol, respectively.

Result: This indicates a not-so-stable complex structure, which is further supported by the lower PROVEAN score of D155Y (Table S6).

Result: This indicates that the mutants D155Y and S171L can also exist independently just like the WT ORF3a protein.

Genomic Surveillance of SARS-CoV-2 Lineages Indicates Early Circulation of P.1 (Gamma) Variant of Concern in Southern Brazil.

PMID: 35171035 2022 Microbiology spectrum

Result: Five specimens (6_LABRESIS, 101_LABRESIS, 195_LABRESIS, 198_LABRESIS, and 211_LABRESIS) were assigned as a P.1.2 sublineage, as they had two synonymous defining mutations (C1912T, and C28789T) tree missense defining mutations (D762G, T1820I, D155Y).

Result: From the five P.1.2 sublineage-defining mutations, three resulted in amino acid substitutions: one in the ORF1ab (D762G/A2550G), one in the ORF3a (T1820I/C5724T), and one in the Nucleocapsid gene (D155Y/G25855T).

Discuss

Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.

PMID: 35266951 2022 Genetics and molecular biology

Method: The latter lineage has nine recognized mutations in addition to the P.1 lineage-defining ones: ORF1ab (synC1150T, synC1912T, D762G, T1820I), ORF3a (D155Y, S180F), M (synC26954T), N (synC28789T), and S glycoprotein (A262S).

Result: Notably, some critical diagnostic sites, whose positive selection signals were detected by us (Table S1), did not seem to be relevant in the networks, indicating no apparent sign of expansion (according to our criteria), at least so far (e.g., ORF1a T1820I and ORF3 D155Y diagnostic sites of P.1.2).

Variations in Orf3a protein of SARS-CoV-2 alter its structure and function.

PMID: 33527091 2021 Biochemistry and biophysics reports

Table: D155Y

Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.

PMID: 34451453 2021 Pathogens (Basel, Switzerland)

Result: This combination was previously described and gave rise to the P.1.2 lineage, which harbors three ORF1ab replacements (synC1912T, D762G, and T1820I), one in ORF3a (D155Y), and one in N protein (synC28789T) (Table 2).

Discussion: The ORF3a:D155Y substitution is located near SARS-CoV caveolin-binding Domain IV.

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