literature

SARS_CoV_2 mutation literature information.

Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.

PMID: 35266951 2022 Genetics and molecular biology

Introduction: Currently, the WHO has identified the Gamma lineage (B.1.1.28.1, P.1 or Gamma; Nextstrain clade 20J/V3) with the following key S mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.

Table: D138Y

E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces.

PMID: 35341044 2022 PeerJ

Introduction: It presents the following mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I.

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.

PMID: 34805715 2021 ACS omega

Introduction: For example, the P.1 lineage detected first in Brazil is characterized by several amino acid (AA) substitutions mostly located either in RBD or in NTD: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I, which are shown to reduce neutralization by some antibodies.

Table: D138Y

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.

PMID: 35017872 2021 Journal of global infectious diseases

Result: L18F, T19A, D80N, D138Y, Y144del, Y145del, K147E, N148S, W152 L,

Discussion: Virulence of SARS-CoV-2 can be associated with mutations in S-protein such as L18F, H69del, V70del, D138Y and Y144del that confer affinity and adhesive properties for better interaction with host cells through surface electrostatic interaction; besides, these mutations are also reported to evade host immune responses against S-protein.

Epidemiology of COVID-19: An updated review.

PMID: 34759999 2021 Journal of research in medical sciences

Table: D138Y

Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.

PMID: 34763050 2021 Infection, genetics and evolution

Result: The Gamma sequences generated herein presented the classical mutational signatures in spike glycoprotein L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F, with some exceptions, as in the sample hCoV-19/Brazil/LMM53965 and hCoV-19/Brazil/LMM54004 that change a guanine for an adenine in 614 position (D614G D614A) and the hCoV-19/Brazil/LMM54029 that change a histidine for a glutamic acid in 655

Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak.

PMID: 34789293 2021 Virology journal

Table: D138Y

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Table: D138Y

The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.

PMID: 34940505 2021 Journal of developmental biology

Introduction: Still, it has been suggested that the great variability in the NTD between these variants, with allosteric influences from other mutations (T20N, P26S, D138Y, R190S; Table 2), could contribute to the observed differences.

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.

PMID: 34910734 2021 PloS one

Result: Some mutations in S protein like L54F, P681L, L18F, S494P, Q613H, L560P, T299A, V1104L, L1063F, Q675R, D138Y, A522S, A845S were only detected in cat, not in any other animal species.

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