Result: Few NTD mutations, namely T20N, P26S, D138Y, and R190S, likely contributed to the increase in ACE2 binding, with ~2, ~1.6, ~1.3 and ~1.8- fold increase compared to D614G, respectively.
Result: In the P.1 Spike we observed mutations in the NTD that decreased recognition (P26S, D138Y, and R190S).
Result: Our results show that all the NTD mutations, namely L18F, T20N, P26S, D138Y and R190S, attenuated the binding of naive-vaccinated plasma Abs.
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.
PMID: 34547629
2021
Biochemical and biophysical research communications
Table: D138Y
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Virology
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