literature

SARS_CoV_2 mutation literature information.

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.

PMID: 34351895 2021 PLoS computational biology

Result: Namely, B.1.1.7 contains N501Y, A570D, D614G, P681H, T716I, S982A, D1118H and deletions on positions 69, 70 and 144.

Molecular Evolution and Epidemiological Characteristics of SARS COV-2 in (Northwestern) Poland.

PMID: 34372500 2021 Viruses

Result: Co-existence of DeltaH69V70, DeltaY144, P681H, T716I, S982A, A570D, N501Y, and D1118H was the signature for the B.1.1.7 (20H/501Y.V1) variant.

Result: The last notable increasing trend was detected for D1118H, from 0.88% in December to 49.68% in February (OR: 9.90, 95% CI 6.83-15.01, p < 0.0001).

Discussion: Our analysis shows that subsequently, three genetic lines of the SARS-CoV-2 molecular evolution have emerged, with the largest clade (Clade 1, lineages B.1.1.*) being the most diverse genetically, with a significant proportion (24.6% for this clade) of the VOC B.1.1.7 variant characterized by a signature combination of the DeltaY144,

PMID: 34409009 2021 Frontiers in public health

Table: D1118H

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: B.1.1.7: H69 deletion, V70 deletion, Y144deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: According to the % frequencies of the genetic markers A570D (23271C>A), D614G (23403A>G), P681H (23604C>A), T716I (23709C>T), S982A (24506T>G), and D1118H (24914GG>C), the Beta.1.1.7/alpha lineage VOC was detected in 80.6% +- 8.3 (mean +- SE), (median of 80.8%) of the total sequencing reads.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: D1118H

Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein.

PMID: 34466389 2021 Meta gene

Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino acid substitutions: N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, two types of events can be observed in 21 out of 24 variants.

Method: V1 = {H69-, V70-, Y144-, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H}.

Method: V1 V3 = {H69 - ,N501Y

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

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