Introduction: This mutation cooccurs with several mutations, including missense mutations (A570D, P681H, T716I, S982A, and D1118H), as well as disruptive in-frame deletions (H69-V70 and Y145).
Table: p.Asp1118His
Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopes.
Introduction: There are seven substitutions (N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H) and three deletions (H69Del, V70Del, and Y144Del) in the spike of the N501Y.V1 variant comparing with the Wuhan-Hu-1 strain (wide type), with N501Y the only mutation in the ACE2 interface of the receptor binding domain (RBD).
The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus.
Introduction: In the case of B.1.1.7, a series of mutations in eight sites including D614G appeared in the spike protein: Delta69Delta70, Delta144Delta145, N501Y, A570D, P681H, T716I, S982A, and D1118H (; GISAID, accessed on 1 December 2020).
Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study.
Introduction: The new variant is characterized by many mutations such as Delta69-70, Delta144, Tyr453Phe, Asn501Tyr, Ala570Asp, Asp614Gly, Phe681His, Thr716Ile, Ser982Ala, and Asp1118His in the spike protein.
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Result: In addition, the UK-VOC contains several nonsynonymous mutations that cause seven aa substitutions at positions N501Y, A570D, D614G, P681H, T716I, S982A, D1118H in S-protein, in which N501Y mutation occurs in the key residue of RBD.
SARS-CoV-2 mutations: the biological trackway towards viral fitness.
Introduction: In addition to these mutations, A570D (RBD), Delta144/145 (S1 subunit), T716I, S982A and D1118H (S2 subunit) are also reported in VUI202012/01.
Table: D1118H
Structural Consequences of Variation in SARS-CoV-2 B.1.1.7.
PMID: 33969357
2021
Journal of cellular immunology
Method: The prefusion SARS-CoV-2 (Wuhan-Hu-1) spike glycoprotein with a single receptor-binding domain up (PDB 6VSB) was used as the basis for modeling D570A, D614G, T716I, S982A and D1118H.
Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?
PMID: 33975397
2021
Journal of Korean medical science
Introduction: The UK SARS-CoV-2 B.1.1.7 variant is defined by multiple spike (S) protein changes (deletion 69-70, deletion 145, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H).
Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development.
Introduction: The B.1.1.7 variant-specific non-synonymous mutations and deletions have been detected in the spike protein including deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.
Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes.
Introduction: The B.1.1.7 lineage (VOC-202012/01) variant identified in patients in the United Kingdom encodes a spike protein with 8 mutations in addition to D614G (Delta69-70, Y144Del, N501Y, A570D, P681H, T716I, S982A, and D1118H).
Result: Analysis of the B.1.1.7 variant and its component mutations showed that the single point mutations had little effect on infectivity (Delta69-70, Y144Del, N501Y, A570D, P681H, and D1118H), except for T716I, which had 5.8-fold decreased infectivity, and S982A, whi
SARS_CoV_2 mutation literature information.
PMID: 
2021
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