SARS_CoV_2 mutation literature information.


  Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
 PMID: 34896696       2022       Journal of infection and public health
Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,


  A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.
 PMID: 34896524       2022       Gene
Table: D1118H
Discussion: Also, there were two other sequences sampled from Shiraz in January 2021, which had five specific mutations as indicator of the Alpha variant (D614G, H69del, N501Y, V70del, Y144del) and were clustered along with the Alpha variants in phylogenetic tree; however, these sequences did not contain the other specific mutations of Alpha variant including A570D, D1118H, L699I, P681H, S982A and T716I.


  Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.
 PMID: 34848355       2022       Infection, genetics and evolution
Result: Among the sub-haplotypes of haplotype 2A variants, sub-haplotype 2A_1 was the most prevalent sub-haplotype in the partly vaccinated rate group, containing three mutations in nsp3 (T183I, A890D, I1412T), seven new mutations in Spike protein (V143del, N501Y, A570, P681H, T716I, D614G, S982A, D1118H), two mutations in ORF8 (R52I, Y73C), and one new mutation in N (S235F).
Table:


  A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).
 PMID: 34842496       2022       Emerging microbes & infections
Result: The D614G (96.4%) substitution was observed in most viral genomes, in addition to multiple mutations defining lineages, such as the mutation set Delta69-70, Delta144, N501Y, A570D, P681H, T716I, S982A, and D1118H for B.1.1.7 viruses.


  Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
 PMID: 34801754       2022       Infection, genetics and evolution
Figure: Mutations associated with the Alpha variant of concern (H69_V70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H) have rapidly
Figure: Some mutations associated with the Beta variant of concern (H69_V70del, Y145del, N501Y, D614G, P681H, and T716I) were present separately before the emergence of the variant in mid-September 2020, while others (A570D, S982A, and D1118H) appeared together at this point.


  Analysis of SARS-COV2 spike protein variants among Iraqi isolates.
 PMID: 34754982       2022       Gene reports
Abstract: Twenty-two distinct mutations were identified within the spike protein regions which were: L5F, L18F, T19R, S151T, G181A, A222V, A348S, L452 (Q or M), T478K, N501Y, A520S, A522V, A570D, S605A, D614G, Q675H, N679K, P681H, T716I, S982A, A1020S,  PMID: 34272947       2022       Clinical infectious diseases
Result: Filtering for more common substitutions (Supplementary Figure 1B) showed a major increase in February in changes associated with B.1.1.7 (eg, S:N501Y, S:A570D, S:T716I, S:S982A, and S:D1118H) while substitutions associated with B.1.2 declined.


  Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
 PMID: 34074255       2021       BMC medical genomics
Discussion: B.1.1.7 variant (multiple spike protein mutations: deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H).


  Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020-March 2021) Using a Statistical Learning Strategy.
 PMID: 35062214       2021       Viruses
Abstract: Structural modeling supported a potential functional impact of the D1118H and L452R mutations.


  Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide.
 PMID: 34066729       2021       Biomedicines
Introduction: This variant is characterized by several amino acid deletions and exchanges, with most of the protein-coding mutations found within the surface-anchored spike (S) protein of the virus: del69-70HV, del144Y, N501Y, A570D, D614G, P681H, T761I, S982A, D1118H (Figure S1a).
Method: These were N501Y, A570D, D614G, P681H, T716I, S982A and D1118H.



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