Introduction: Announced in December 2020 and probably emerging in November 2020, the Alpha variant, the most commonly isolated variant worldwide, is characterized by the presence of the N501Y, A570D, P681H, T716I, S982A, and D1118H substitutions and deletions at positions 69/70 and 144 in the S gene.
Pierce into Structural Changes of Interactions Between Mutated Spike Glycoproteins and ACE2 to Evaluate Its Potential Biological and Therapeutic Consequences.
PMID: 34931119
2022
International journal of peptide research and therapeutics
Result: According to the results of the multiple sequence alignment, the mutations of the EPI_ISL_601443 variant were as follows: H69 deletion, V70 deletion, Y144 deletion, N501Y substitution, A570D substitution, D614G substitution, P681H substitution, T716I substitution, S982A substitution, and D1118H substitution.
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.
Discussion: We have shown that the molecular mechanism underlying the fitness advantage of Alpha in vivo is largely dependent on a few changes in S, including three amino acid deletions (H69, V70 and Y144) and six substitutions (N501Y, A570D, P681H, T716I, S982A and D1118H).
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of Concern.
Result: The relative abundance of each marker from most to least abundant was D614G > A570D > 69-70del and 144del > D1118H > S982A > P681H and T716I > N501Y > E584K (Table 2).
Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.
Figure: B.1.1.7 contains the spike (S) protein mutations A570D, D614G, D1118H, H69-V70del, N501Y, P681H, S982A, T716I, and Y145del.
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine.
PMID: 34929375
2022
Travel medicine and infectious disease
Result: The tested mutations include spike mutants of T716I, N501Y, A570D, P681H, D1118H, 982A, deletion 69-70, deletion 145, with lineage B.1.1.7 variant spike.
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
Result: Three (3.6%) sequences belonged to the Alpha variant (lineage B.1.1.7/clade GR/501Y.V1) and showed a mutational pattern of N501Y, A570D, D614G, P681H, Table: D1118H
Discussion: Alpha variant B.1.1.7 was found in one case each from vaccine breakthrough, mild and dead patient category showing nonsynonymous mutations of N501Y, A570D, D614G, P681H, T716I, S982A, D1118H and three deletions of H69del, V70del, and Y144del.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Viruses
Browser Board
Co-occurred Entities
Filtrator
ViMRT