Discussion: To note that, L84S clade is also dependent on another variant located in the ORF1ab at 8782C>T, and this makes the possibility that L84S clade could be more ancestral than the L clade especially with the presence of COVID19 asymptomatic patients.
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh.
Result: In addition, other co-evolving mutations found were (241C>T, 3037C>T, 14408C>T, 23403A>G), (28881G>A, 28882G>A, 28883G>C), (8782C>T, 28144T>C), (4444G>T, 8371G>T, 29403A>G).
SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay.
Result: In March and early April, ORF8 mutation L84S and the associated C8782 T SNP were most abundant (>1/3 of sequences) (Figure 2A, C, Figures S2 and S3).
Discussion: Uruguayan clade S viruses are characterized by the key mutations T28144 C, causing the AA replacement L84S in ORF8, and C8782 T, in agreement with global clade S strains.
Discussion: 8782C > T(ORF1ab) and 28144 T > C (ORF8), has been identified among researchers in several genome databases.
Discussion: The previous research was carried out on 103 genomes of SARS-CoV-2 for both co-mutations (8782C > T and 28,144 T > C) which classified the virus as S / L types (Yin, 2020).
A Founder Effect Led Early SARS-CoV-2 Transmission in Spain.
Discussion: (2020), C8782T substitution, which is also a silent mutation, was present in 28 out of 95 samples, although this mutation was only present in 2 samples (EPI_ISL_428718 and EPI_ISL_437317) in our study, which indicates that this mutation is not as common as in Europe for the viral isolates in Turkey and may be related with isolates from other countries.
Discussion: <
Discussion: C8782T was previously seen in more than 10 isolates in Guangdong province of China (Lu et al., 2020) and proposed to be clade specific in a study performed on 313 SARS-CoV-2 genomes (Li, Li, Cui, and Wu, 2020).
Discussion: Both C8782T and G11083T mutations were found to be mostly present in Oceania isolates, where followed by North America and Europe subsequently (Pachetti et al., 2020).
5Result: Other two major clades are called ""S,"" named after the mutation in ORF8 L84S (Ceraolo and Giorgi,), also characterized by a silent C8782T genomic mutation, and ""V,"" from the ORF3a:G251V mutation, almost always co-occurring with the NSP6:L37F event, and identified by early phylogenetic studies (Forster et al.,)."
Table: C8782T
Characterizing SARS-CoV-2 mutations in the United States.
Result: Among them, 3 mutations are synonymous ones (i.e., 3037C>T-(F106F), 8782C>T-(S76S), and 18060C>T-(L7L)) and 8 mutations are the missense mutations (i.e., 14408C>T-(P323L), 23403A>G-(D614G), 25563G>T-(Q57H), 1059C>T-(T85I), 28144T>C-(L84S), 17858A>G-(Y541C), 17747C>T-(P504L), and
Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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