In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Table: C28854T
Discussion: The third common mutation occurred in ORF3a at position G 25563 T (Q75H) followed by a mutation in the N gene at position C28854T (S194L).
Genomic Variations in SARS-CoV-2 Genomes From Gujarat: Underlying Role of Variants in Disease Epidemiology.
Abstract: Among the missense mutations present in the Gujarat SARS-CoV-2 genomes, C28854T (Ser194Leu) had an allele frequency of 47.62 and 7.25% in deceased patients from the Gujarat and global datasets, respectively.
Result: The mutations G25563T, C26735T, and C18877T (>55%), followed by C2836T, C22444T, and C28854T (>40%), followed by G21724T, C29750T, C18568T, G4300T, and A2292C (>13%) in viral genomes were sequenced from Gujarat.
Discussion: The predicted SIFT score of the mutation
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Abstract: From missense mutations found from Gujarat SARS-CoV-2 genomes, C28854T, deleterious mutation in the nucleocapsid (N) gene was significantly associated with patients' mortality.
Result: From missense mutations found from Gujarat SARS-CoV-2 genomes, C28854T, deleterious mutation in the nucleocapsid (N) gene was significantly associated with patients' mortality.
Table: C28854T
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
Result: Finally, a significant growing trend from 7% in September to 27% in October/November samples was revealed for the missense mutation S194L (28854C>T), in line with a similar trend observed worldwide (09/2020, 13% and 11/2020, 21%).
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Discussion: For mutation C28854T (S194L), a change of secondary structure of RNA was observed resulting in an increase in positional entropy (blue: high positional entropy, red: low positional entropy) and a decrease in base pair probability of the nucleotide bases (blue: low base pair probability, red: high base pair probability) (Figure S4).
Discussion: Of these three mutations, the C28854T (S194L) variation has already been reported to be associated with highly severe cases.
Discussion: Whereas 38% and 20% of the cases with the mutation A26194T and C28854T were fatal compared to an average mortality rate of 10.5%, which highlights that these mutations are positively correlated with COVID-19 severity and mortality.
Result: Among the nine variations, six (C6312T, C8637T, A10124G, C17518T, C23664T
Result: Sequence analysis showed a common ancestor of B.1.524 lineage (T241-T3037-T14408-G23403), with the acquisition of nine mutations (C6312T, C8637T, A10124G, C17518T, C21516T, C21622A, C23664T, A28133T, and C28854T) that could have seeded transmission clusters of the two closely related groups in Sabah and Selangor (Tables 2 and 3).
Table: C28854T
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: By contrasting the allelic imbalance between symptomatic and asymptomatic hosts in a polymorphic site fashion, we found a single significant association of the C28854T mutation (ANOVA; F=20.5; P=0.003).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Saudi journal of biological sciences
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