literature

SARS_CoV_2 mutation literature information.

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2.

PMID: 35341060 2022 PeerJ

Discussion: Within North America, it was reported that one of the top mutations, 27964C>T-(S24L) in the ORF8 protein, has an unusually strong gender dependence.

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Result: Notably, after analyzing 28,726 complete genome sequences, none of them have mutations 28144T>C-(L84S) and 27964C>T-(S24L) happened simultaneously.

Result: Similar to 27964C>T-(S24L), although 17858A>G-(Y541C), 17747C>T-(P504L) are in the final list in Table 1, more than 87% of them were detected in the United States.

Result: The co-mutations of the second groups have eight unique single mutations: 1059C>T-(T85I), 14408C>T-(P323L), 23403A>G

Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity.

PMID: 33900399 2021 JAMA network open

Result: Several variants were associated with lower hospitalization rate, including 12809C>T (L4182F ORF1ab, 3 of 91 hospitalizations [3.3%] vs 22 of 211 hospitalizations [10.4%]; chi21 = 4.215; P = .04) and 27964C>T (S24L ORF8, 0 of 91 hospitalizations [0%] vs 13 of 211 hospitalizations [6.2%]; chi21 = 5.878; P = .01).

AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.

PMID: 34512928 2021 Computational and structural biotechnology journal

Result: H1-3-3 had previous 5 specific sites and 8 new missense mutation sites (C1059T, C10319T, A18424G, C21304T, G25907T, C27964T, C28472T, and C28869T) (Table 5, Table 6), which increased gradually between December 01, 2020 and February 02, 2021 in the USA.

Table: C27964T

Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.

PMID: 34735950 2021 Computers in biology and medicine

Discussion: Some mutations (for example, C27964T in ORF8) have been found to have gender dependence with a presumed ratio of 2:1.

A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.

PMID: 34841355 2021 Current research in microbial sciences

Discussion: This finding contradicts with the results of a study conducted in the United States of America, that found the 27964C > T-(S24L) mutation to be more prevalent in females than in males.

Characterizing SARS-CoV-2 mutations in the United States.

PMID: 32818213 2020 Research square

Abstract: We identify that one of the top mutations, 27964C>T-(S24L) on ORF8, has an unusually strong gender dependence.

Result: The ORF8 protein also has two high-frequency mutations, 28144T>C-(L84S) and 27964C>T-(S24L).

Result: The first group involves 5 mutations 1059C>T-(T85I), 14408C>T-(P323L), 23403A>G

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