SARS_CoV_2 mutation literature information.


  Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.
 PMID: 33170902       2020       PloS one
Result: Following the first appearance it started emerging in other European countries mainly in Spain, this clade has also emerged in the USA in mid-Jan and gives birth to a new cluster containing 444 strains all sharing a C17747T mutation (Leu5828Leu, ORF1ab) starting from mid-Feb.


  Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
 PMID: 33184173       2020       Proc Natl Acad Sci U S A
Result: In addition, the signature SNVs with high allelic association are typically located in distant regions, except for type IV signature SNVs C17747T and A17858G and the sub-VI SNVs (refer to the next section and.
Result: Two type IV signature SNVs, C17747T and A17858G, first coappeared in strain EPI_ISL_413456 in the United States on February 20, 2020, and the coefficient of allelic association is R2(C17747T, A17858G) = 0.973.



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