Introduction: Moreover, the two most frequent mutations were A97V (14408C > T) and P323L (13730C > T) and were found predominantly in Europe, North America, and, more recently, in India.
Introduction: Out of the top five, P323L (13730C > T), and A97V (14408C > T) presented amino acid mutations that could affect the structure of the protein.
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Abstract: Apart from that the group of SNVs became dominant, which is represented by two nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), a few emerging groups of SNVs were recognized with sharply increased monthly incidence ratios of up to 70% in November 2020.
Introduction: The majority of SARS-CoV-2 genomes have evolved with a dominant SNV cluster represented by nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), in addition to C241T at the upstream of
Introduction and Characteristics of SARS-CoV-2 in North-East of Romania During the First COVID-19 Outbreak.
Discussion: Specifically, mutations at positions 241 (non-coding), 3037 C > T, 14408 C > T, 20268 20003A > G, and 23403 A > G are frequent in European samples and were identified early in the pandemic evolution, as a signature for one of the superspreaders that originated from Wuhan.
Discussion: This mutation co-evolved with other three major mutations, 3037 C > T, 14408 C > T, and 23403 A > G.
In-Silico analysis reveals lower transcription efficiency of C241T variant of SARS-CoV-2 with host replication factors MADP1 and hnRNP-1.
PMID: 34307830
2021
Informatics in medicine unlocked
Introduction: Top variants in the SARS-CoV-2 genome include high-frequency variants including C241T, C1059T, C3037T, C14408T, A23403G, G25563T, and G28883C, out of which the C241T variant had a 99 % frequency with 0.505 entropy by October 2020.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: Three mutations were found in > 95% of the genomes: A23403G (S:D614G), C14408T (ORF1ab:L4715), and C3037T (ORF1ab:F924), which are signatures of the B.1 and derived lineages that spread early in the pandemic.
Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2.
PMID: 34403832
2021
Infection, genetics and evolution
Table: C14408T
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
R
Discussion: In this regard, we have initially targeted five well-characterized missense mutations spanning different genomic regions of SARS-CoV-2, i.e., D614G (23403A>G), P323L (14408C>T), Q57H (25563G>T), R203K (28881G>A), and G204R (28883G>C), and specific nested PCR amplicons were sequenced using DNA-seq.
Discussion: Interestingly, the P323L (14408C>T) mutation has been reported to co-evolve with D614G worldwide; this adaptation of the virus might strengthen SARS-CoV-2 G614 strain replication rates and infectivity.
Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Abstract: The most frequent mutation that occurred in 98% isolates was 3037C>T which is a synonymous change that usually accompanied 3 other mutations that include 241C>T, 14408C>T (P323L in RdRp) and Table: 14408C>T
Discussion: Those mutations include 3037C>T (98%), 14408C>T (98%) and 23403A>G (97%) where the last two are non-synonymous mutations (P4715L in ORF1ab or P323L in RdRp and D614G in Spike protein).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Computers in biology and medicine
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