Discussion: Specifically, mutations at positions 241 (non-coding), 3037 C > T, 14408 C > T, 20268 20003A > G, and 23403 A > G are frequent in European samples and were identified early in the pandemic evolution, as a signature for one of the superspreaders that originated from Wuhan.
Discussion: This mutation co-evolved with other three major mutations, 3037 C > T, 14408 C > T, and 23403 A > G.
In-Silico analysis reveals lower transcription efficiency of C241T variant of SARS-CoV-2 with host replication factors MADP1 and hnRNP-1.
PMID: 34307830
2021
Informatics in medicine unlocked
Introduction: Top variants in the SARS-CoV-2 genome include high-frequency variants including C241T, C1059T, C3037T, C14408T, A23403G, G25563T, and G28883C, out of which the C241T variant had a 99 % frequency with 0.505 entropy by October 2020.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: Three mutations were found in > 95% of the genomes: A23403G (S:D614G), C14408T (ORF1ab:L4715), and C3037T (ORF1ab:F924), which are signatures of the B.1 and derived lineages that spread early in the pandemic.
Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
PMID: 34812411
2021
Informatics in medicine unlocked
Result: The C14408T mutation substitute Proline (P) with Leucine (L) in position 314 of non-structural protein 12b (NSP12b), a RNA-dependent RNA polymerase (RdRp).
Figure: The A23403G, C3037T, C14408T, and C241T are the most widespread mutations globally.
Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa.
Introduction: Another interesting feature of the G clades is that the associated C14408T mutation adjacent to the RNA dependent RNA polymerase (RdRp) putatively increases the mutation rate as Pachetti et al.
Introduction: One sample from January 24th 2020 had only the A23403G (D614G) but not the C3037T and C14408T mutations which usually associate with A23403T in clade G.
Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
Result: Excluding the substitution at position 241 in the 5' UTR, the top three most frequent mutations were the C3037T (59.9%), C14408T (59.9%) and A23403G (D614G) (57.4%).
Result: From March to December, substitutions appeared consistently at the genomic positions C241T, C3037T, C14408T and A23403G
Discussion: One of the LD sets included A23403G (D164G), C14408T and C3037T which were reported to be the most frequent mutations in many parts of the world and also found to be the most frequent mutations in this study.
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Result: All strains clustered under this group, including those sequenced in the current study, possessed the three GISAID clade G genetic variants, C241T, C3037T, and A23403G with an additional mutation C14408T.
Result: The C14408T and A23403G were missense mutations (Table 2).
Result: The C14408T is a common mutation used to define B.1 in the Pangolin system, and it is also used to define a haplogroup A2a4 (another SARS-CoV-2 clustering system).
Result: The C14408T was encoded for substitution of proline with leucine at position 323 in nsp12 of ORF1ab ( PMID: 34767598
2021
PLoS pathogens
Result: Synonymous SNPs from this Farm A isolate included C1059T, C3037T, C6336T, G12795A, C14408T, C20930T, A23064C, A23403G, G25563T, C25936T, C28887T, were also identical to those of MW474212 from a human in Washington State.
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: Our samples contained SNVs in one of the early strain types (VI) that spread out of China (C241T, C3037T, C14408T and A23403G mutations) which has the haplotype of allelic associations 241T-3037T-14408T-23403G, detected in high frequency worldwide (December 2020), and that may be involved in increasing the fitness of the SARS-CoV-2 virus.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in microbiology
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