Abstract: To date, type VI, characterized by the four signature SNVs C241T (5'UTR), C3037T (nsp3 F924F), C14408T (nsp12 P4715L), and A23403G (Spike D614G), with strong allelic associations, has become the dominant type.
Method: It is noteworthy that we observed two nucleotides with a nonnegligible variation frequency relative to their neighboring regions: 1) C241T (5' UTR) with a variation frequency of 45.5% (and this nucleotide was in high allelic association with C3037T
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.
Abstract: The three most common variants were linked, and included C3037T, C14408T (nsp12: P323L) and A23403G (S: D614G) mutations.
Discussion: The linkage of four changes (C241T, C3037T, C14408T, A23403T) has been described in a comprehensive study of Spike protein variants especially related to the D614G transition.
Discussion: We characterised the three most prevalent variants detected in 40/44 completed genome sequences, namely C3037T (synonymous substitution) and two non-syno
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
Method: Later, 20A emerged in European outbreak from 19A parents having C3037T, C14408T, and A23403G as distinctive features.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A
Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.
Result: In the severely affected group, however, 241C>T, and 23403A>G coincided, and 3037C>T and 14408C>T occurred in subsets of them.
Result: Of note, in the mildly affected group, four most common mutations (241C>T, 3037C>T, 14408C>T, and 23403A>G) coincided.
Discussion: Although the 14408C>T (RdRp P323L) mutation was predominantly found in severely affected patients in the present study, further studies will be required to elucidate whether this RdRp mutation has any significant impact on the viability and infectivity of SARS-CoV-2 and the
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
5Result: The ""major group,"" which, of 95 isolates, was comprised of 66 (69.4%), revealed 4 coexisting SNPs: 241C>T in the five prime untranslated region (5' UTR), 3037C>T (F106F) in the NSP3 gene, 14408C>T (P323L) in the NSP12 gene, and 23403A>G (D614G) in the S gene (Table 1)."
Discussion: Few strains from Europe and North America since February 2020 have shown the emergence of mutations like 3037C>T (F106F, NSP3), 23403A>G (
SARS_CoV_2 mutation literature information.
PMID: 
2020
The journal of physical chemistry letters
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