Result: Excluding the substitution at position 241 in the 5' UTR, the top three most frequent mutations were the C3037T (59.9%), C14408T (59.9%) and A23403G (D614G) (57.4%).
Result: From March to December, substitutions appeared consistently at the genomic positions C241T, C3037T, C14408T and A23403G
Discussion: One of the LD sets included A23403G (D164G), C14408T and C3037T which were reported to be the most frequent mutations in many parts of the world and also found to be the most frequent mutations in this study.
Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Result: All strains clustered under this group, including those sequenced in the current study, possessed the three GISAID clade G genetic variants, C241T, C3037T, and A23403G with an additional mutation C14408T.
Result: The C14408T and A23403G were missense mutations (Table 2).
Result: The C14408T is a common mutation used to define B.1 in the Pangolin system, and it is also used to define a haplogroup A2a4 (another SARS-CoV-2 clustering system).
Result: The C14408T was encoded for substitution of proline with leucine at position 323 in nsp12 of ORF1ab ( PMID: 34767598
2021
PLoS pathogens
Result: Synonymous SNPs from this Farm A isolate included C1059T, C3037T, C6336T, G12795A, C14408T, C20930T, A23064C, A23403G, G25563T, C25936T, C28887T, were also identical to those of MW474212 from a human in Washington State.
Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
PMID: 34812411
2021
Informatics in medicine unlocked
Result: The C14408T mutation substitute Proline (P) with Leucine (L) in position 314 of non-structural protein 12b (NSP12b), a RNA-dependent RNA polymerase (RdRp).
Figure: The A23403G, C3037T, C14408T, and C241T are the most widespread mutations globally.
A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.
PMID: 34841355
2021
Current research in microbial sciences
Result: A total of 12 mutations were found in Germany in which four mutations 241C > T, 3037C > T, 14408C > T and 23403A > G were found common and existed at a frequency of 87.38%, 89.32%, 77.62% and 88.35%, respectively.
Result: After analyzing the samples of Brazil, a total of 12 mutations were found in which four of them (241C > T, Table: 14408C > T
Discussion: In this study the prevalent and important co-mutations (241C > T, 3037C > T, 14408C > T, 23403A > G) which were identified mostly prevailed in the South Asian SARS-CoV-2 isolates and aligned with those identified in the European countries.
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: Our samples contained SNVs in one of the early strain types (VI) that spread out of China (C241T, C3037T, C14408T and A23403G mutations) which has the haplotype of allelic associations 241T-3037T-14408T-23403G, detected in high frequency worldwide (December 2020), and that may be involved in increasing the fitness of the SARS-CoV-2 virus.
Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.
PMID: 34866979
2021
Saudi journal of biological sciences
Conclusion: The SARS CoV-2 variants iso
Result: Our analysis showed that the most frequently changed nucleotide were C3037T (silent mutation) and A23403G (D614G) each of which occurred in 57 variants out of 58, followed by C14408T (P4715L) and C241T (5'UTR) which were found in 56 and 55 variants, respectively.
Result: The coexistence of C241T (5'UTR), C3037T (ORF1ab), C14408T (ORF1ab) and A23403G (S gene) was observed in 55 variants.
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China.
Result: Eight single nucleotide polymorphisms (SNPs) were identified, including C242T, C313T, C3037T, C14408T, A23403G, G28881A, G28882A, and G28883C.
Discussion: A total of eight bases in the viral RNA sequence were mutated (referred to as: Gene Bank ID: MW301121) as follows: C241T, C313T, C3037T, C14408T, A23403G, and GGG28881AAC.
Discussion: We determined the Sichuan-2020 sequence belongs to haplogroup A2a4 (diagnostic variants: C241T<
Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.
PMID: 32451533
2020
American journal of clinical pathology
Discussion: Sequencing of viral RNA from FFPE lung tissue from the case 1 autopsy showed mutations most consistent with a subset of the Western European Clade A2a (C3037T, C14408T, A23403G), with mutations enriched in New York State A2a cases (C1059T and G25563T).
An updated analysis of variations in SARS-CoV-2 genome.
Abstract: Despite some variations being in low frequency rate in some continents, C14408T and A23403G variations on Nsp12 and S protein, respectively, observed to be the most prominent variations all over the world, in general, and both cause missense mutations.
Abstract: It is also notable that most of isolates carry C14408T and A23403 variations simultaneously and also nearly all isolates carrying the G25
Figure: SARS-CoV-2 isolate numbers carrying the variations Green: Isolate numbers carrying C14408T, Blue: Isolate numbers carrying A23403G, Red: Isolate numbers carrying G25563T and Yellow: Isolate numbers carrying GGG to AAC variations between 28881-28883.
SARS_CoV_2 mutation literature information.
PMID: 
2021
PeerJ
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