AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
PMID: 34512928
2021
Computational and structural biotechnology journal
Introduction: We further found that the 4 highly linked sites (C241T
Result: For the UK, the 5 of 6 haplotypes (including H1-1-1, H1-2-1, H1-4-1, H1-4-2, and H1-4-3), which derived from H1 with previous 4 specific mutation sites (C241T, C3037T, C14408T, and A23403G), accounted for 91.95% of the population (Table 4).
Result: H1-3-2 had previous 5 specific sites (C241T, C3037T, C14408T, A23403G, and G25563T) and C1059T (Table 5, Table 6), which had a stable prevalent trend between December 01, 2020 and February 02, 2021 in the USA.
Table: C14408T
Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure.
Result: Clade 20A defined by C14408T (Nsp12/RdRp) and A23403G (S: D614G) was seen in 58% of the samples, clade 19A defined by positions 8782C (Nsp3) and 14408C (Nsp12/RdRp) was seen in 38% and 20B denoted by positions C3037T (Nsp3: 106F); A23403G (S: D614G); C14408T (Nsp12/RdRp: P4715L) and G28881A and
Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.
PMID: 34606987
2021
Infection, genetics and evolution
Discussion: This finding is consistent with an earlier study in a genotyping analysis of 588 SARS-CoV-2 strains where P4715L mutation (14408C > T) was reported to be located in a critical protein necessary for RNA replication.
Identification and characterization of SARS-CoV-2 clusters in the EU/EEA in the first pandemic wave: additional elements to trace the route of the virus.
PMID: 34637920
2021
Infection, genetics and evolution
Figure: The relative entry point of the C14805T and C14408T mutations in the tree, their area of influence (shaded area), the inferred node from which evolved the SS4 cluster and the central node at the root of the SS4 cluster (filled yellow circle) are shown.
Discussion: 4) through the acquisition of the C14408T mutation.
Discussion: At the beginning of February, the virus, with this mutation, was present in several European countries; this is supported by the high number of SS4 genomes detected in several European countries that carried the additional C14408T mutation only.
Discussion: Conversely, the C14408T resulted in the amino acid substitution P > L in the RdRp.
Discussion: Following its first detection in Europe (EPI_ISL_406862), the SS4
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation.
Abstract: Furthermore, NSP12 323L variant, encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy, Italy, that carries a Pro323Leu amino acid substitution in NSP12, showed increased ability to activate RIPK1.
Introduction: The SARS-CoV-2 C14408T variant that carries a Pro323Leu amino acid substitution in RNA-dependent RNA polymerase (RdRp, NSP12), the central component of coronaviral replication and transcr
Introduction: The mechanism behind the apparent positive selection of the variant with C14408T mutation is unclear with most studies focused on the Spike protein.
Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model.
4Method: A python script (https://github.com/hridoy04/counting-mutations) was used to partition that data set into two subsets (RdRp wild-type or ""C"" variant: 9,815; and mutant or ""T"" variant: 27 364) based on the presence of RdRp: C14408T mutatio
Introduction: Yin reported that the 5'-untranslated region (5'-UTR) mutation 241C>T is co-occurring with three other mutations, 3037 C>T (NSP3: C318T), 14408C>T (RdRp: p.P323L), and 23403A>G (S: p.D614G).
Discussion: For example, the parent node sequences of C1 containing C2416T/C3037T/C14408T/A23403G/G25563T was reported to be associated with an international business conference in Boston, resulting in extensive international spread and low-level community transmission in Europe.
Discussion: Genomes of another sister cluster C2, harboring the C26735T variant in addition to common signatures of C3037T/C14408T/A23403G/C18877T/G25563T, have been found mainly in Asia (93 genomes as of October 9, 2020).
Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa.
Introduction: Another interesting feature of the G clades is that the associated C14408T mutation adjacent to the RNA dependent RNA polymerase (RdRp) putatively increases the mutation rate as Pachetti et al.
Introduction: One sample from January 24th 2020 had only the A23403G (D614G) but not the C3037T and C14408T mutations which usually associate with A23403T in clade G.
Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
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