Result: All strains clustered under this group, including those sequenced in the current study, possessed the three GISAID clade G genetic variants, C241T, C3037T, and A23403G with an additional mutation C14408T.
Result: The C14408T and A23403G were missense mutations (Table 2).
Result: The C14408T is a common mutation used to define B.1 in the Pangolin system, and it is also used to define a haplogroup A2a4 (another SARS-CoV-2 clustering system).
Result: The C14408T was encoded for substitution of proline with leucine at position 323 in nsp12 of ORF1ab ( PMID: 34760404
2021
PeerJ
Result: Excluding the substitution at position 241 in the 5' UTR, the top three most frequent mutations were the C3037T (59.9%), C14408T (59.9%) and A23403G (D614G) (57.4%).
Result: From March to December, substitutions appeared consistently at the genomic positions C241T, C3037T, C14408T and A23403G
Discussion: One of the LD sets included A23403G (D164G), C14408T and C3037T which were reported to be the most frequent mutations in many parts of the world and also found to be the most frequent mutations in this study.
Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
Introduction: Another interesting feature of the G clades is that the associated C14408T mutation adjacent to the RNA dependent RNA polymerase (RdRp) putatively increases the mutation rate as Pachetti et al.
Introduction: One sample from January 24th 2020 had only the A23403G (D614G) but not the C3037T and C14408T mutations which usually associate with A23403T in clade G.
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Abstract: The most frequent mutation that occurred in 98% isolates was 3037C>T which is a synonymous change that usually accompanied 3 other mutations that include 241C>T, 14408C>T (P323L in RdRp) and Table: 14408C>T
Discussion: Those mutations include 3037C>T (98%), 14408C>T (98%) and 23403A>G (97%) where the last two are non-synonymous mutations (P4715L in ORF1ab or P323L in RdRp and D614G in Spike protein).
AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
PMID: 34512928
2021
Computational and structural biotechnology journal
Introduction: We further found that the 4 highly linked sites (C241T
Result: For the UK, the 5 of 6 haplotypes (including H1-1-1, H1-2-1, H1-4-1, H1-4-2, and H1-4-3), which derived from H1 with previous 4 specific mutation sites (C241T, C3037T, C14408T, and A23403G), accounted for 91.95% of the population (Table 4).
Result: H1-3-2 had previous 5 specific sites (C241T, C3037T, C14408T, A23403G, and G25563T) and C1059T (Table 5, Table 6), which had a stable prevalent trend between December 01, 2020 and February 02, 2021 in the USA.
Table: C14408T
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
Result: Clade 20A defined by C14408T (Nsp12/RdRp) and A23403G (S: D614G) was seen in 58% of the samples, clade 19A defined by positions 8782C (Nsp3) and 14408C (Nsp12/RdRp) was seen in 38% and 20B denoted by positions C3037T (Nsp3: 106F); A23403G (S: D614G); C14408T (Nsp12/RdRp: P4715L) and G28881A and
Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
R
Discussion: In this regard, we have initially targeted five well-characterized missense mutations spanning different genomic regions of SARS-CoV-2, i.e., D614G (23403A>G), P323L (14408C>T), Q57H (25563G>T), R203K (28881G>A), and G204R (28883G>C), and specific nested PCR amplicons were sequenced using DNA-seq.
Discussion: Interestingly, the P323L (14408C>T) mutation has been reported to co-evolve with D614G worldwide; this adaptation of the virus might strengthen SARS-CoV-2 G614 strain replication rates and infectivity.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Scientific reports
Browser Board
Co-occurred Entities
Filtrator
ViMRT