In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Result: The mutations C241T, A23403G, C14408T, and C3037T appeared together in 83 % of Indian SARC-CoV-2 variants.
Table: C14408T
Discussion: Moreover, the present study showed that A23403G (D614G) co-occurred with three other mutations that were C241T, C14408T, and C3037T, a similar pattern of co-existence was reported by, while observed the co-existent of C14408T and A23403G.
Discussion: The second most dominant nonsynonymous mutation occurred in ORF1 a/b at position C14408T which changed the amino
Genomic Diversity of SARS-CoV-2 in Algeria and North African Countries: What We Know So Far and What We Expect?
Discussion: It is worth mentioning that the Spike D614G mutation accompanies other frequent mutation sites in the ORF1ab (NSP3:C3037T, NSP3:T428I and NSP12:C14408T) region, the mutation at position 241 (C241T) targeting the 5'UTR, as well as the mutations at positions 203 and 212 in the Nucleocapsid protein (N:RG203KR, N:G212V), in the receptor binding domain (RBD) of
SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load.
Result: A positive significant association was also observed for the C14408T SNP, and a negative association for the C241T SNP (Supplementary Table S5).
Result: A significant negative association was found for the C3037T C14408T, and G25563T SNPs (Supplementary Table S9).
Result: We included 12 additional SNPs (C241T, C1191T, C3037T, G10427A, C14408T, C15352T, C18877T, A23403G, G25563T, C26735T, T27
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Abstract: Apart from that the group of SNVs became dominant, which is represented by two nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), a few emerging groups of SNVs were recognized with sharply increased monthly incidence ratios of up to 70% in November 2020.
Introduction: The majority of SARS-CoV-2 genomes have evolved with a dominant SNV cluster represented by nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), in addition to C241T at the upstream of
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Abstract: Studies have demonstrated that the C14408T and A234
Result: Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to miserable mutations.The spike D614G amino acid change has become the most common variant since December 2019.
Table: C14408T
Discussion: reported C14408T variant on Nsp12 and A23403G variation on S protein, and both cause significant mutations and changes in virus variants worldwide.
Abstract: Reverse transcription fluorescence resonance energy transfer-polymerase chain reaction (FRET-PCRs) were designed against the two most common mutations in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (A23403G in the spike protein; C14408T in the RNA-dependent RNA polymerase).
Method: Genomic RNA of two SARS-CoV-2 viruses from american type culture collection (ATCC) served as controls and as quantitative standards: 2019-nCOV/USA-WA1/2020 which does not contain the A23403G and the C14408T mutations, and 201/501Y.V1 which contains both mutations.
Method: The 6-carboxyfluorescein (6-FAM)-labeled probes were further designed to contain the unique A23403G or PMID: 34157472
2021
Computers in biology and medicine
Table: 14408C>T
Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type.
Introduction: Moreover, the two most frequent mutations were A97V (14408C > T) and P323L (13730C > T) and were found predominantly in Europe, North America, and, more recently, in India.
Introduction: Out of the top five, P323L (13730C > T), and A97V (14408C > T) presented amino acid mutations that could affect the structure of the protein.
Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.
5Result: Global characterization of the SARS-CoV-2 variants from all ~50,500 viral genomes sequences, suggested three major variants groups as 1,771 isolate Group 1 ""C241T, C
Result: A23403G and C14408T were observed at higher frequencies (>50%) in all the genomes, while G25563T, C13730T, G11083T C6312A, C241T, C3037T, G11083T, C13730T, C28311T, C6312A and C23929T mutations were predominated (>24% frequency) in Indian genomes (Additional File1).
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: Three mutations were found in > 95% of the genomes: A23403G (S:D614G), C14408T (ORF1ab:L4715), and C3037T (ORF1ab:F924), which are signatures of the B.1 and derived lineages that spread early in the pandemic.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Saudi journal of biological sciences
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