Abstract: When the mutations were evaluated, C3037T, C14408T and A23403G were found to be the most common nucleotide substitutions among the viral isolates in Turkey, which are mostly seen as linked mutations and are part of a haplotype observed high in Europe.
Result: In more than 40% of the viral isolates, one or more of nucleotide substitutions of C3037T, C14408T ,A23403G, and G25563T were observed, which are present in the coding regions for the Nsp3, RNA-dependent RNA polymerase, spike glycoprotein and ORF3a protein, respectively (Table 1).
Table: PMID: 32697968
2020
Cell
7Figure: As an example, in this tree, the region from approximately 12:30 to 3 o'clock represents GISAID's ""GR"" clade, defined both by mutations we are tracking in this paper that carry the G614 variant (the GISAID G clade, defined by mutations A23403G, C14408T, C3037T, and a mutation in the 5' UTR (C241T, not shown here), and an additional 3-position polymorphism: G28881A + G28882A + G28883C."
Figure: One is in the RdRp protein (nucleotide C14408T resulting in a P323L amino acid change), one in Spike (nucleotide A23403G
RdRp mutations are associated with SARS-CoV-2 genome evolution.
Abstract: It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.
Abstract: Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect.
Abstract: Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread.
Introduction: Although the higher number of mutations in genomes with RdRp 14408C>T mutation was suggested to be caused by lower fidelity of the mutant enzyme, it co
Comprehensive Analyses of SARS-CoV-2 Transmission in a Public Health Virology Laboratory.
Result: All samples sequenced were associated with clade 20, harboring the clade's mutations A23403G and C14408T (Nextstrain nomenclature).
Result: As specified, 7/14 mutations were associated with the 20B and 20C clades (Table 3), 4/14 mutations were detected in all sequences compared to the reference sequence (C241T, C3037T, C14408T, A23403G), and the rest of the mutations (3/14) were uniquely observed in S2, S3, S6, S7 and S8 (Table 3).
Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV-2.
Result: Another study reported that this variant has co-evolved with three coding region mutations (3037C > T, 14408C > T, and 23403A > G) of nsp3, RNA primase and spike glycoprotein.
Geographic and Genomic Distribution of SARS-CoV-2 Mutations.
5Result: Specifically, the four mutations C241T, C3037T, C14408T, and A23403G are observed in all samples from the clade ""G"" (named after the Spike D614G mutation) and its two derivative GH (further characterized by the ORF3a:Q57H mutation) and GR (affected by the trinucleotide mutation in the Nucleocapsid gene, inducing a RG203KR mutation)."
Result: Three mutations show similar frequency with A23403G: C14408T, C241T, and C3037T (Figure 3A).
Table: C14408T
Characterizing SARS-CoV-2 mutations in the United States.
Introduction: Based on genotyping results, top eight missense mutations (i.e., 14408C>T-(P323L), 23403A>G-(D614G), 25563G>T-(Q57H), 1059C>T-(T85I), 28144T>C-(L84S), 17858A>G-(Y541C), 17747C>T-(P504L), and 27964C>T-(S24L)) are identified, in addition to three synonymous mutations (i.e., 3037C>T-(F106F), 8782C>T-(
Molecular Epidemiology Analysis of SARS-CoV-2 Strains Circulating in Romania during the First Months of the Pandemic.
Result: These mutations, C3037T, C14408T (P323L in Nsp12) and A23403G (D614G in S), were present in all Romanian sequences.
Discussion: A mutation profile consisting in C3037T, C14408T, A23403G (mutation found in all the Romanian sequences), next to C241T was found to be specific to the Europe cluster and was initially associated with higher pathogenicity.
SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution.
Abstract: Four genetically linked mutations known as the globally dominant SARS-CoV-2 haplotype (C241T, C3037T, C14408T and A23403G) were found in the majority of consensus sequences.
Result: Four genetically linked mutations previously described as the globally dominant haplotype in April 2020 were found in the majority of our consensus sequences: C241T (100%; 5'UTR region), C3037T (98.6%; silent mutation), C14408T (100%; resulting in P4715L/P323L amino acid change in ORF1ab) and A23403G (100%; resulting in D614G amin
Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Turkish journal of biology
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