Abstract: The first wave is a group of four mutations (C241T, C3037T, C14408T and A23403G [this being the amino acid change D614G]; all designated 0 to 1 below).
Prevalence of a Single-Nucleotide Variant of SARS-CoV-2 in Korea and Its Impact on the Diagnostic Sensitivity of the Xpert Xpress SARS-CoV-2 Assay.
Introduction: The SNVs that define B.1.497 include C241T, C1059T, C11916T, C14408T, C16560T, A20675T, A23403G, G25563T, and G29179T.
Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease.
PMID: 33506644
2022
Transboundary and emerging diseases
Result: Some mutations were more frequent than others; for example, the 241C>T, 3037C>T, 14408C>T, and the 23403A>G (also known as the D614G mutation in the S protein), were each seen in 58 of the genomes (Table S3).
Cross-sectional genomic perspective of epidemic waves of SARS-CoV-2: A pan India study.
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach.
PMID: 32933378
2022
Journal of biomolecular structure & dynamics
Result: Only C14408T variations caused amino acid exchange (P323L) on Nsp12 of SARS-CoV-2, shown in Figure 1.
Result: Three variations were found on the gene sequence encoding Nsp12: C14408T (first reported by Pachetti et al.,), C14805T and C15324T.
SARS-CoV-2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions.
PMID: 33835709
2022
Transboundary and emerging diseases
Result: Other less frequent variants were observed in ~19% of samples constituting the known co-occurrence of variants; [C241T-C3037T-C14408T-A23403G] and [C241T-C3037T-C14408T-A23403G-G25563T], occurring in clade G (B.1), which is prevalent in Europe, Oceania, South America and Africa and clade GH (B.1.*), prevalent in North America (Mercatelli and Giorgi, 2020).
Result: The [B.1.*/20A] samples did not show [G1397A-T28688C-G29742T] substitutions but instead harboured [C241T-C3037T-<
Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.
5Result: The four mutations, C241T, C3037T, C14408T, and A23403G, were observed in all 20 genome sequences from the clade ""G"" isolates (named after the D614G mutation)."
Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication.
Result: The patient presented 6 nucleotide mutations and 2 amino acid changes from the reference sequence Wuhan-1 (GenBank accession number: NC_045512): C96T, C241T, G12769T, C14408T, A20268G, A23403G, being present in the 12 consensus sequences analyzed from the patient.
Genomic Diversity of SARS-CoV-2 in Algeria and North African Countries: What We Know So Far and What We Expect?
Discussion: It is worth mentioning that the Spike D614G mutation accompanies other frequent mutation sites in the ORF1ab (NSP3:C3037T, NSP3:T428I and NSP12:C14408T) region, the mutation at position 241 (C241T) targeting the 5'UTR, as well as the mutations at positions 203 and 212 in the Nucleocapsid protein (N:RG203KR, N:G212V), in the receptor binding domain (RBD) of
In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Result: The mutations C241T, A23403G, C14408T, and C3037T appeared together in 83 % of Indian SARC-CoV-2 variants.
Table: C14408T
Discussion: Moreover, the present study showed that A23403G (D614G) co-occurred with three other mutations that were C241T, C14408T, and C3037T, a similar pattern of co-existence was reported by, while observed the co-existent of C14408T and A23403G.
Discussion: The second most dominant nonsynonymous mutation occurred in ORF1 a/b at position C14408T which changed the amino
SARS_CoV_2 mutation literature information.
PMID: 
2022
National science review
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