Result: Binding level results of T29I, V367F, A706V, and A831V demonstrated that these substitutions had low binding affinity in HLA-A01:01, HLA-B07:02, and HLA-B35:01 compared to the wild type, while H49Y, Q239K, V483A, D839Y, S943P, A1078S, and P1263L substitutions still had strong binding affinity with HLA molecules.
Result: For variant S proteins, T29I, H49Y, Q239K, V367F, V483A, PMID: 33024961
2020
Research square
Result: Of the other 15 Spike variants, two are in perfectly-conserved residues (V615I/F, P1263L) and two in mostly-conserved residues in highly-conserved regions (A831V, A829T/S), indicating likely-functional changes.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Frontiers in immunology
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