literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.

PMID: 35028838 2022 Environmental science and pollution research international

Abstract: The onset of the D614G mutation and subsequent changes to D614 before March, later G614 in mid-March, and S943P, A831V, D839/Y/N/E in April were observed in Asian and European countries.

Discussion: A few mutant forms like S943P was reported on the 13th of April in Belgium, A831V and D839/Y/N/E during April in Europe.

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline.

PMID: 32954666 2021 Transboundary and emerging diseases

Table: A831V

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring.

PMID: 33676232 2021 Biochemical and biophysical research communications

Result: Eleven spike mutations were not found associated with ORF8 variants: L8V/W, N234Q, Q239K, L452R, A475V, G476S, V483A, F490L, V615I/F, A831V and D839Y/N/E.

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Table: A831V

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 33976134 2021 Nature communications

Result: Of the other 15 spike-gene mutations, two are in perfectly conserved residues (V615I/F, P1263L) and two in mostly conserved residues in highly conserved regions (A831V, A829T/S), indicating likely functional changes.

Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.

PMID: 34346317 2021 Computers in biology and medicine

Result: In combination, structure-based online servers predicted 17 nonsynonymous mutations (L8V, L8W, L18F, S71F, Y145H, M153T, F157S, S221L, S221W, S247R, G476S, L611F, A831V, A852V, A879S, C1247F, and C1254F) with decreased stability, and 7 nonsynonymous mutations (H49Y, S50L, D215H,

An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.

PMID: 32511374 2020 bioRxiv

Method: Two mutants associated with European Covid-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G and the other contains four mutations including Q239K, A831V, D614G and D839Y.

Result: Interestingly, the SARS-CoV-2 spike binding region harbors three residues that have been recently reported to have mutated in new strains from Europe and USA: D614G, A831V and D839Y/N/E).

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 32577641 2020 bioRxiv

Result: First, we investigated Sarbecovirus conservation of 14 amino acids in the spike protein in which mutations appear to be accumulating in the SARS-CoV-2 population, namely D614G, L5F, L8V/W, H49Y, Y145H, Q239K, V367F, G476S, V483A, V615I/F, A831V, D839Y/N/E, S943P, P1263L.

Result: Likewise, two others, V615I/F and P1263L are mutations of perfectly conserved amino ac

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.

PMID: 32730807 2020 Cell

Result: These variants include single amino acid change such as Y145del, Q414E, N439K, G446V, K458N, I472V, A475V, T478I, V483I, F490L, and A831V, as well as the double amino acid changes including

Table: A831V

Discussion: Another important finding is that natural variants capable of affecting the reactivity to neutralizing mAbs were almost all located in the RBD region (except A831V) because all antibodies used in this study were targeting the RBD.

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.

PMID: 32989130 2020 Proc Natl Acad Sci U S A

Method: Two mutants associated with European COVID-19 patients were constructed using CHARMM-GUI: one is the main strain mutant D614G, and the other contains four mutations including Q239K, A831V, D614G, and D839Y.

Result: Interestingly, the SARS-CoV-2 S binding region harbors three residues that have been recently reported to have mutated in new strains from Europe and the United States: D614G, A831V, and D839Y/N/E.

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