Introduction: To assess the neutralization breadth of RBD-NP-elicited Abs, we evaluated serum neutralizing activity against a panel of pseudotyped viruses comprising wild-type (D614G) SARS-CoV-2 S and nine single-residue SARS-CoV-2 RBD mutants detected in clinical isolates (G446S, Y453F, L455F, T478I, E484A/K, F486L, S494P, and N501Y) as well as the B.1.1.7 (H69-V70 deletion, Y144 deletion, N501Y, A570D, P681H, T716I, PMID: 33804556
2021
Viruses
Discussion: shows that an African variant L18F, D80A, D215G, K417N, E484K, N501Y, D614G, A701V propagates much faster than a variant without L18F mutation in the presence of plasma antibodies collected from donors infected in the first wave of epidemic in South Africa (June-August 2020).
Method: B.1.351 virus contained the following spike mutations: L18F, D80A, D215G, del-L242_244, R246I, K417N, E484K, N501Y, D614G, A701V.
Table: A701V
The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?
PMID: 33907511
2021
International journal of biological sciences
Introduction: The 501Y.V2 variant is characterized by carrying nine mutations in S protein (L18F, D80A, D215G, R246I, Delta242-244, K417N, E484K, N501Y, A701V) (Table 1), three of which (K417N, E484K and N501Y) locate in the RBD of the S protein.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Abstract: The most common sets of spike mutations in this lineage (now designated as B.1.526) are L5F, T95I, D253G, E484K or S477N, D614G, and A701V.
Method: Human plasma samples were assayed for neutralization activity against lentiviruses pseudotyped with SARS-CoV-2 spike containing a 21-amino acid cytoplasmic tail deletion and either D614G or mutations corresponding to lineage B.1.526 (L5F, T95I, D253G, E484K, D614G, and A701V).
R
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Result: The SA-VOC has seven aa substitutions in the S-protein, including D80A, D215G, K417N, E484K, N501Y, D614G, and A701V, and three aa 'LLA' are deleted between positions 241-243.
Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mutation T478K.
Introduction: 11 Virtually all variants of concern contain mutations in the SARS-CoV-2 Spike protein, such as variant B.1.351 (Spike mutations K417N, E484K, N501Y, D614G, and A701V) and variants B.1.427/B.1.429 (Spike mutations S13I, W152C, L452R, and D614G), and many of these reside on the receptor-binding domain (RBD), a region located between residues 350-550 of Spike and directly binding to the human ACE2.
Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?
PMID: 33975397
2021
Journal of Korean medical science
Introduction: The SARS-CoV-2 B.1.351 variant in South Africa has eight mutations involving the S protein (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, and A701V).
Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes.
Introduction: The B.1.351 lineage variant identified in South Africa that has become the predominant genotype in that population is more heavily mutated than B.1.1.7, with 9 mutations (L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, and A701V), 3 of which (K417N, E484K, and N501Y) are in the receptor binding domain (RBD).
Table: A701V
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: B.1.351 Spike contains also a consecutive deletion of the three amino acids L242, A243, and L244 immediately N-terminal to loop N5 (245-264aa) as well as the replacements D80A, D215G, and A701V.
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
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