Introduction: The Beta variant, discovered a few days after the Alpha in samples collected between March and November 2
Result: Considering several parameters, including estimated informedness and amplicon lengths, we observed that the subset comprising the SNPs K417N, N439K, Y453F, S477N, T478K, E484K, N501Y, A570D, H655Y, Q677H, P681H, I692V, A701V, and716I, would lead to a test providing an acceptable compromise between informedness (0.76) and minimal amplicon length (896 bp).
Table: A701V
A short plus long-amplicon based sequencing approach improves genomic coverage and variant detection in the SARS-CoV-2 genome.
Result: L18F, 69-70 Del, D80A, Y144Del, L242Del, A570D, A701V and T716I.
Genomic characterization of the dominating Beta, V2 variant carrying vaccinated (Oxford-AstraZeneca) and nonvaccinated COVID-19 patient samples in Bangladesh: A metagenomics and whole-genome approach.
Abstract: Noteworthily, the receptor binding domain (RBD) region of S protein of all the isolates harbored similar substitutions including K417N, E484K, and N501Y that signify the Beta, while D614G, D215G, D80A, A67V, L18F, and A701V substitutions were commonly found in the non-RBD region of Spike proteins.
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.
Method: The Beta virus used in these studies contained the following mutations: D80A, D215G, L242-244 deleted, K417N, E484K, N501Y, D614G, A701V.
Method: To construct the expression plasmids for the S protein of Beta, a construction of trimeric S of the Wuhan strain was used as the template and nine pairs of primers of S (L18F forward primer 5'-GAGCAGCCAGTGCGTGAATTTCACCACCAGAACCCAGCTG-3', L18F reverse primer 5'-CAGCTGGGTTCTGGTGGTGAAATTCACGCACTGGCTGCTC -3'; D80A forward primer 5'-GCACCAAGAGATTCGCCAATCCTGTGCTGCC-3' and PMID: 34906769
2022
Biomedicine & pharmacotherapy
Introduction: Strain B.1.351 contains nine mutations within spike protein, including the L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, and A701V.
Table: A701V
Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
PMID: 34896696
2022
Journal of infection and public health
Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,
A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Result: first detected in New York (L5F, T95I, D253G; E484K or S477N; D614G, and A701V), appear together consistently after the week of October 4th, 2020, though the fact that many of these mutations are shared with other phylogenetic lineages makes it difficult to conclude that the variant originated at this time point.
Figure: 1 associated with the Iota variant of interest are L5F, D253G, E484K, S477N, D614G, A701V).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Science immunology
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