Introduction: The Beta variant, discovered a few days after the Alpha in samples collected between March and November 2
Result: Considering several parameters, including estimated informedness and amplicon lengths, we observed that the subset comprising the SNPs K417N, N439K, Y453F, S477N, T478K, E484K, N501Y, A570D, H655Y, Q677H, P681H, I692V, A701V, and716I, would lead to a test providing an acceptable compromise between informedness (0.76) and minimal amplicon length (896 bp).
Table: A701V
SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity.
Method: For ELISA, ADCP and ADCD assays, SARS-CoV-2 original and Beta variant full spike (L18F, D80A, D215G, K417N, E484K, N501Y, D614G, A701V, 242-244 del), RBD original and Beta (K417N, E484K and N501Y, D614G) and NTD original and Beta (L18F, D80A, D215G and 242-244 del) proteins were expressed in Human Embryonic Kidney (HEK) 293F suspension cells by transfecting the cells with the respective expression pl
Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia.
Result: Taken together, the missense mutations, L18F, N501Y, A701V and G1223C seem to have increased the binding affinity of the spike protein, whereas mutations D80A, D215G, K417N, Discussion: In addition, A701V mutation, adjacent to the furin cleavage site of spike protein subunit S1 and S2, in B.1.524 of Malaysian lineage was also found in SARS-CoV-2 beta (B.1.351) strains and SARS-CoV-2 i B.1.526 (USA).
Discussion: Our analysis also suggests, AU.2 is not correlated to B.1.524, as B.1.524 carry different mutations (A701V) in spike protein.
Misidentification of the SARS-CoV-2 Mu variant using commercial mutation screening assays.
Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability.
PMID: 35163572
2022
International journal of molecular sciences
Result: Strikingly, the positions of mutational changes A570D, D614G, T716I, S982A in the S-B.1.1.7 states (Figure 5C,D) and positions D614G and A701V in the S-B.1.351 conformations (Figure 5E,F) are aligned
Result: The increased mobility of mutational sites is particularly apparent in the open state of the S-B.1.351 variant (Figure 3F), where all the modified positions L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, and A701V displayed a significant plasticity.
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape.
PMID: 35149224
2022
Infection, genetics and evolution
Result: We observed that the nsSNVs P80R, A701V, K417N, K417T, L18F, and R246I had greater antigenicity scores in regard to the REF sequence.
Table: A701V
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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