literature

SARS_CoV_2 mutation literature information.

A Simple Reverse Transcriptase PCR Melting-Temperature Assay To Rapidly Screen for Widely Circulating SARS-CoV-2 Variants.

PMID: 34288729 2021 Journal of clinical microbiology

Introduction: The B.1.1.7 variant has a number of mutations in the spike protein, including single-nucleotide polymorphisms (SNPs) resulting in N501Y, A570D, D614G, and P681H mutations and deletions at amino acids 69 and 70 and 144Y.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: A570D

Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.

PMID: 34312390 2021 Nature communications

Method: The B.1.1.7 Spike we used carries the mutations found in GISAID Accession Number EPI_ISL 668152: del 69-70, del145, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.

Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity.

PMID: 34314772 2021 Virus research

Introduction: The B.1.1.7 SARS-CoV-2 variant strain exhibits missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.

Result: Genome sequencing of the new B.1.1.7 SARS-CoV-2 strain presented missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.

Transformations, Lineage Comparisons, and Analysis of Down-to-Up Protomer States of Variants of the SARS-CoV-2 Prefusion Spike Protein, Including the UK Variant B.1.1.7.

PMID: 34346753 2021 Microbiology spectrum

Result: As can be seen, only A570D and D614G involve glue point partners within the Spike protein.

Table: A570D

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.

PMID: 34351895 2021 PLoS computational biology

Result: Namely, B.1.1.7 contains N501Y, A570D, D614G, P681H, T716I, S982A, D1118H and deletions on positions 69, 70 and 144.

Molecular Evolution and Epidemiological Characteristics of SARS COV-2 in (Northwestern) Poland.

PMID: 34372500 2021 Viruses

Result: Co-existence of DeltaH69V70, DeltaY144, P681H, T716I, S982A, A570D, N501Y, and D1118H was the signature for the B.1.1.7 (20H/501Y.V1) variant.

Result: Two mutations, A570D and N501Y, were in perfect linkage; therefore, the increase in incidence from 0.88% in December to 51.32% in February (OR: 10.12, 95% CI 6.83-15.37, p < 0.0001) was the same.

Discussion: Our analysis shows that subsequently, three genetic lines of the SARS-CoV-2 molecular evolution have emerged, with the largest clade (Clade 1, lineages B.1.1.*) being the most diverse genetically, with a significant proportion (24.6% for this clade) of the VOC B.1.1.7 variant characterized by a signature

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.

PMID: 34385690 2021 Nature structural & molecular biology

Abstract: The B.1.1.7-specific A570D mutation introduces a molecular switch that could modulate the opening and closing of the RBD.

The Emergence and Spread of Novel SARS-CoV-2 Variants.

PMID: 34409009 2021 Frontiers in public health

Table: A570D

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

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