literature

SARS_CoV_2 mutation literature information.

Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics.

PMID: 34064904 2021 Viruses

Discussion: Recently, the United Kingdom has reported that a large proportion of new cases in South East England belonged to a new single phylogenetic cluster defined by multiple spike protein mutations (deletions 69-70 and 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H

Discussion: The B1.525 variant harbors a Q677H mutation, the variant B1.1.7 reported in the United Kingdom carries A570D and P681H mutations, the P1 variant from Brazil shows the H655Y mutation, and the recently reported B.1.617 strain in India shows a P681R change.

Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide.

PMID: 34066729 2021 Biomedicines

Abstract: Amino acid exchanges within the SARS-CoV-2 spike protein variant of B.1.1.7 affect inter-monomeric contact sites within the trimer (A570D and D614G) as well as the ACE2-receptor interface region (N501Y), which comprises the receptor-binding domain (RBD) of the spike protein.

Introduction: This variant is characterized by several amino acid deletions and exchanges, with most of the protein-coding mutations found within the surface-anchored spike (S) protein of the virus: del69-70HV, del144Y,

Result: This additional destabilization in B.1.1.7 could be explained by the A570D mutation (Figure 2a, orange box).

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

PMID: 34074255 2021 BMC medical genomics

Discussion: B.1.1.7 variant (multiple spike protein mutations: deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H).

SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.

PMID: 34109031 2021 Annals of medicine and surgery (2012)

Introduction: Other considerable modifications are A570D, D614G, P681H, 144Y deletion, and 69/70 deletion.

Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021.

PMID: 34128696 2021 mSystems

Figure: (A) Deletion of nucleotides 21765 to 21770 (deletion of amino acids HV69-70); (B) deletion of nucleotides 21991 to 21993 (deletion of amino acid Y144); (C) mutation A23063T (amino acid change N501Y); (D) mutation C23271A (amino acid change A570D).

Proliferation of SARS-CoV-2 B.1.1.7 Variant in Pakistan-A Short Surveillance Account.

PMID: 34136461 2021 Frontiers in public health

Abstract: Based on the partial sequencing of SGTF samples 93.5% (n = 29/31) showed the characteristic N501Y, A570D, P681H, and Result: Based on the partial sequencing of spike gene of SGTF samples, 93.5% (n = 29/31) showed the characteristic N501Y, A570D, P681H, and T716I mutations found in the B.1.1.7 variant.

Table: A570D

Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic.

PMID: 34146731 2021 Infection, genetics and evolution

Introduction: Among the mutations in the B.1.1.7, nine mutations, including H69-V70 deletion (Delta69/Delta70), Y144 deletion (Delta144), N501Y, A570D, D614G, P681H, T716I, S982A, and D1119H, were located in the viral spike protein.

Introduction: The 501Y Variant 2 contains 17 mutations, including H69-V70 deletion (Delta69/Delta70), Y144 deletion (Delta144), N501Y, A570D, P681H, T716I, S982A, D1118H, T1001I, A1708D,

PMID: 34160124 2021 Chembiochem

Introduction: These mutations in this strain may enhance virus transmissibility and infectivity, including the deletion of residues 69-70 and 144 and the substitution of A570D, D614G, T716I, S982A, D1118H, P681H, K417N, K417T, E484 K and N501Y.

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

PMID: 34166617 2021 Cell reports

Method: The mutations (Delta69/70, Delta144, N501Y, A570D, D614G, P681H, S982A, T716I and D1118H or K417N, E484K and N501Y) were introduced by amplification with primers with similar Tm.

Result: In addition to RBD N501Y and NTD DeltaH69/V70, B.1.1.7 is defined by further S mutations across S2 (T716I, S982A, and D1118H) and S1 (DeltaY144, A570D, and

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.

PMID: 34166623 2021 Immunity

Method: The variant B.1.1.7 (GISAID: EPI_ISL_601443) was constructed with total of 9 mutations including 69-70del, 144del, N501Y, A570D, D614G, P681H, T716I, S982A and D1118H.

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