literature

SARS_CoV_2 mutation literature information.

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: B.1.1.7: H69 deletion, V70 deletion, Y144deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.

PMID: 34442775 2021 Microorganisms

Abstract: However, the key mutations-N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) were also recorded in spike protein.

Result: The most common amino acid substitutions were D614G (83.4%) followed by N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) in Spike (S) protein.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: According to the % frequencies of the genetic markers A570D (23271C>A), D614G (23403A>G), P681H (23604C>A), T716I (23709C>T), S982A (24506T>G), and D1118H (24914GG>C), the Beta.1.1.7/alpha lineage VOC was detected in 80.6% +- 8.3 (mean +- SE), (median of 80.8%) of the total sequencing reads.

Result: Interestingly, the A570D (23271C>A) substitution was observed in a significantly lower percentage, i.e., 44.41%.

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.

PMID: 34452356 2021 Viruses

Result: Intriguingly, one of the genomes (EPI_ISL_1567985) encoded S-L452R, S-N501Y, and S-G1219V associated with six other amino acid changes in the spike (A570D, D614G, P681H, T716I, S982A, I1221V), most interestingly comprising D614G and also P681H (Figure 4B).

Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.

PMID: 34452511 2021 Viruses

Result: As an example of this processing, the sequence '1212G(G404G) 1501T(N501Y) 1709A(A570D)' with 100 counts would have the covariants of '1212G(G404G)', '1501T(N501Y)', '1709A(A570D)', '1212G(G404G) 1501T(N501Y)', '1212G(G404G) 1709A(A570D)', '1501T(N501Y) 1709A(A570D)' and '1212G(G404G) 1501T(N501Y) 1709A(A570D)', and contribute 100 counts to each.

Result: For instance, in a sample where '1501T(N501Y)' has an abundance of 0.3

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: A570D

Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein.

PMID: 34466389 2021 Meta gene

Method:

Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino acid substitutions: N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, two types of events can be observed in 21 out of 24 variants: .

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

PMID: 34534263 2021 PLoS pathogens

Method: We used the following amino acids replacements and deletions in Spike for each lineage-based COG-UK defined changes for each lineage; Beta (B1.351; L18F, D80A, D215G, R246L, K417N, E484K, N501Y, A701V), Gamma (P.1; L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y H655Y, T1027I), Alpha (B.1.1.7; Delta69-70, D144,

Filtrator