Method: We used the following amino acids replacements and deletions in Spike for each lineage-based COG-UK defined changes for each lineage; Beta (B1.351; L18F, D80A, D215G, R246L, K417N, E484K, N501Y, A701V), Gamma (P.1; L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y H655Y, T1027I), Alpha (B.1.1.7; Delta69-70, D144, PMID: 34462752
2021
bioRxiv
Abstract: Residues involved in the most ubiquitous D614G mutation and the A570D mutation of the highly contagious UK SARS-CoV-2 variant are predicted ab initio from our model.
Introduction: In fact, the most ubiquitous spike protein mutation to date, the D614G, and the A570D mutation in the recently emerged highly contagious UK SARS-CoV-2 strain both appeared among our predicted set of residues, the latter having been discovered after the completion of our calculations.
Result: On the contrary, an A570D mutation is observed in the same residue in the newly emerged and highly infectious B.1.1.7 strain in the United Kingdom.
Discussion: However, a different mutation at residue 570 (A570D) has indeed appeared in the recently emerged m
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
Introduction: In September 2020, the B.1.1.7 lineage emerged as a variant of concern in the United Kingdom (UK), subsequently termed the alpha variant, with 9 spike protein mutations (del69/70HV, del144Y, N501Y, A570D, D614G, P681H, T761I, S982A, and D1118H).
Introduction: These mutations, specifically N501Y, A570D and D614G, appear to restructure the protein-protein interaction between the spike protein and the ACE2 receptor leading to an overall enhanced efficacy of cellular u
Table: A570D
SARS-CoV-2 monoclonal antibodies with therapeutic potential: Broad neutralizing activity and No evidence of antibody-dependent enhancement.
Result: List of variations displayed in structure (nearest residue if in loop/termini region): H69del V70del(69) Y144del(143) N501Y A570D D614G P681H(674) T716I S982A D1118H as seen in Table 3.
Table: A570D
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
Result: At least 3,776 S protein variants belonging to alpha (B.1.1.7) variant lineage were identified, in which all contain 2 deletion events (amino acids 69 to 70 and 144) and 7 mutations (N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H).
Result: Dual mutants containing D614G and other amino acid changes, including those under positive selection or observed in VOCs (L5F, L18F, S98F, W152L/C, E154K, L222V, and A262S in S1-
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity.
PMID: 34722330
2021
Frontiers in cellular and infection microbiology
Result: In contrast, T716I, A570D, D118H and A701V mutations caused a modest reduction in viral infectivity.
Result: The results indicated that pseudovirions bearing HV69-70 deletion, 144 deletion, E484K, D614G, P681H, S982A or D1118H single-site mutations were more stable than SARS-CoV-2 WT, whereas A570D and T716I mutations decrease the stability of SARS-CoV-2 pseudovirion.
Discussion: Pseudovirion with HV69-70 deletion could enhance the infectivity of the virus, while single-site mutation T716I, A570D,
Result: Some important hotspot mutations like H69-, V70-, Y144-, A222V, N501Y, A570D, P681H, and P681R identified in this study are associated with the different SARS-CoV-2 variants of concern like Alpha, Beta, Gamma, and Delta.
SARS_CoV_2 mutation literature information.
PMID: 
2021
PLoS pathogens
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