Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data.
PMID: 33755190
2021
Journal of cellular physiology
Introduction: Novel mutations in the spike protein of B.1.1.7 (deletion 69-70, 144 and substitution K417N, K417T, E484K, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, and many others) might have altered the SARS-CoV-2 ability to transmit and infect.
Result: Comparative genomics inspection of genomes obtained from the UK, South Africa, Brazil, and other parts of the world revealed that the spike protein had acquired multiple crucial mutations including (K417N, K417T, E48
The N501Y spike substitution enhances SARS-CoV-2 transmission.
Method: Individual point mutations in the spike gene (Delta69-70, Delta145, N501Y, A570D, P681H, T716I, S982A, D1118H and UK-8x) were introduced into an D614G infectious cDNA clone of the 2019n-CoV/USA_WA1/2020 (WA1/2020) strain as described previously.
Result: Yet, significant fitness gains were observed in recipients for N501Y and A570D as well as UK-8x, suggesting more efficient tran
Result: except that Delta69-70 no longer impacted fitness, while A570D increased and two other mutations (S982A and D1118H) decreased fitness.
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
Introduction: To assess the neutralization breadth of RBD-NP-elicited Abs, we evaluated serum neutralizing activity against a panel of pseudotyped viruses comprising wild-type (D614G) SARS-CoV-2 S and nine single-residue SARS-CoV-2 RBD mutants detected in clinical isolates (G446S, Y453F, L455F, T478I, E484A/K, F486L, S494P, and N501Y) as well as the B.1.1.7 (H69-V70 deletion, Y144 deletion, N501Y, A570D, P681H, T716I, PMID: 33758892
2021
medRxiv
Introduction: The B.1.1.7 variant has a number of mutations in the spike protein including single nucleotide polymorphisms (SNPs) resulting in N501Y, A570D, D614G and P681H mutations, and deletions at amino acids 69-70 and 144Y.
SARS-CoV-2 genome sequencing from COVID-19 in Ecuadorian patients: a whole country analysis.
Result: Three of the analyzed sequences showed the aminoacid changes T183I, A890D, I1412T, P323L, L493F, N501Y, T553I, A570D, D614G, P681H, T716I, S982A, D1118H, Q27, R52I, Y73C, D3L, R203K, G204R and S235F placing them in the B.1.1.7 lineage.
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations.
Introduction: The lineage, characterized by nine spike protein mutations (deletions: 69-70 HV, 145V; substitutions: N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), started to spread rapidly in mid-October 2020 to constitute in January 2021 86% of all SARS-CoV-2 genomes sequenced in England.
Introduction: Of particular note were nine mutations in the spike gene compared to prototype sequences; a 69-70 deletion (the cause of S-gene target failure), Y144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D118H, with seven of these distinct to B.1.1.7.
Vaccine Breakthrough Infections with SARS-CoV-2 Variants.
PMID: 33882219
2021
The New England journal of medicine
Discussion: Some of the substitutions in Patient 1 (T95I, del144, E484K, A570D, D614G, P681H, and D796H) were shared with B.1.526 (T95I, E484K, and D614G), and three substitutions were shared with Patient 2 (in whom the variants T95I, G142V and del144, F220I, R190T, R237K, R246T, and D614G were detected).
Introduction: This mutation cooccurs with several mutations, including missense mutations (A570D, P681H, T716I, S982A, and D1118H), as well as disruptive in-frame deletions (H69-V70 and Y145).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of cellular physiology
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