literature

SARS_CoV_2 mutation literature information.

Dynamics of SARS-CoV-2 Alpha (B.1.1.7) variant spread: The wastewater surveillance approach.

PMID: 35074352 2022 Environmental research

Result: Compared to the Wuhan-Hu-1 variant, VOC Alpha is characterized by the occurrence of 9 genetic markers in the S gene (69-70del, 144del, N501Y, A570D, D614G, P681H, T716I, S928A and D118H).

Result: The relative abundance of each marker from most to least abundant was D614G > A570D > 69-70del and 144del > D1118H > S982A > P681H and T716I > N501Y > E584K

Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal.

PMID: 35083576 2022 Archives of virology

Result: Therefore, the impact of the N439K, S477N, N501Y, and A570D mutations on protection by mAbs was evaluated.

Table: A570D

Figure: B.1.1.7 contains the spike (S) protein mutations A570D, D614G, D1118H, H69-V70del, N501Y, P681H, S982A, T716I, and Y145del.

Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.

PMID: 35101265 2022 Vaccine

Table: A570D

Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater.

PMID: 35115523 2022 Nature communications

Result: N501Y+A570D), this observation cannot be taken as evidence that these lineages were derived from such a host.

Figure: Pseudoviruses containing SARS-COV-2 Spike with N501Y/A570D were used as a control as this is known to be capable of infecting rodent cells.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.

PMID: 35118474 2022 bioRxiv

Method: D614G spike mutation: D614G; Alpha (B.1.1.7) spike mutations: Delta69-70, Delta144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; Beta (B.1.351) spike mutations: L18F, D80A, D215G, Delta242-244, R246I, K417N, E484K, N501Y, D614G, A701V; Delta (B.1.61

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model.

PMID: 35273335 2022 Communications biology

Discussion: In another study that used engineered rescued viruses derived from the USA_WA1/2020 strain, the hamster model appeared useful to detect weak fitness advantages and increases in transmissibility of viruses that carry the N501Y and A570D spike mutations.

Design of SARS-CoV-2 Variant-Specific PCR Assays Considering Regional and Temporal Characteristics.

PMID: 35285246 2022 Applied and environmental microbiology

Result: As a result, for the Alpha variant, we identified nine mutations in the spike gene: S:Delta69/70, S:Delta144, S:N510Y, S:A570D, S:D614G, S:P681H, S:T716I, S:S982A, and S:D1118H.

Result: For the Alpha variant, we found three acceptable mutations, S:A570D, S:T716I

SARS-CoV-2 infection after vaccination in Italian health care workers: a case report.

PMID: 35283546 2022 National Academy science letters. National Academy of Sciences, India

Abstract: Their genotyping performed on RNA extracts highlighted the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) sequence variants, all indicative of VOC 202012/01-lineage B.1.1.7, suggesting a common source of infection.

Result: The genotyping performed first by Real-time PCR and then confirmed by direct sequencing proved the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) variants, indicative of VOC 202,012/01-lineage B.1.1.7, in all samples suggesting a common source of infection.

Figure: Sections from the electropherograms showing the 69/70, N501Y, A570D, and D614G (a.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Table: A570D

Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?

PMID: 35308382 2022 Frontiers in microbiology

Table: A570D