literature

SARS_CoV_2 mutation literature information.

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Result: Among substitution, two in nsp1 (Q63L, G82S), seven in nsp2 (R197C, K261 N, F275L, K292E, V378I, D448 N, V627F) and one deletion at N449, Nine amino acids substitutions in nsp3 (L1174I, T1246I, K1308 N, T1754I, T2016K, T2408F, L2564F, A2619V, Q2702H), two substitutions (

Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

PMID: 35171928 2022 PloS one

Table: p.Ala4489Val

SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.

PMID: 35386683 2022 Frontiers in cellular and infection microbiology

Result: Notably, all the mutations associated with the recovered group (S2015R, Y789Y, T2016K, S194*, A4489V) showed a frequency flip, whereas two mutations associated with the mortality group showed a shift in their frequency from our cohort to global level.

Discussion: Moreover, a significant frequency flip (p-value = 0.0001) was seen for the five mutations, S2015R, Y789Y, T2016K, S194*, and A4489V, in the recovered with a low global presence, indicating that the mutations associated with COVID-19 recovery are deselected by the virus during its evolution.

Clinical and whole genome characterization of SARS-CoV-2 in India.

PMID: 33529260 2021 PloS one

Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (6312 C>A{T2016N}, 11083G>T{L3606F}, 13730C>T{A4489V} in ORF1ab; 28311C>T{P13L} in the N gene) were observed in the sample (OUMRK1090/2020) collected from patient with travel history to UAE.

Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (6312 C>T{

A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.

PMID: 33705994 2021 Computers in biology and medicine

Table: A4489V

An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.

PMID: 34067745 2021 Viruses

Result: It was noted that 331/406 sequences had a conserved pattern in the ORF1ab (T2016K, A4489V) and N: P13L, Figure 3 (blue and its shades).

Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.

PMID: 34157472 2021 Computers in biology and medicine

Table: A4489V

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: Mutational analysis of the 7213 SARS-CoV-2 genome sequences revealed the following high rate recurrent mutations in the ORF1ab polyprotein sequence: T265I and D448del (nsp2 coding region), T2016K (nsp3), G3278S (nsp5), L3606F (nsp6), A4489V and P4715L (RNA dependent RNA polymerase), and P5828L, Y5865C (RNA helicase region).

Table: A4489V

Genomic diversity of SARS-CoV-2 in Malaysia.

PMID: 34760404 2021 PeerJ

Result: The non-synonymous mutations were in the ORF1ab (T2016K, L3606F, A4489V) and N (P13L).

Table: A4489V

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