literature

SARS_CoV_2 mutation literature information.

Genomic diversity of SARS-CoV-2 in Malaysia.

PMID: 34760404 2021 PeerJ

Result: Excluding the substitution at position 241 in the 5' UTR, the top three most frequent mutations were the C3037T (59.9%), C14408T (59.9%) and A23403G (D614G) (57.4%).

Result: From March to December, substitutions appeared consistently at the genomic positions C241T, C3037T, C14408T and A23403G.

Result: The second LD set comprised C3037T, C14408T and A23403G mutations in viruses isolated from March to December and involving a single synonymous and non-synonymous mutation in ORF1ab, together with a si

Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.

PMID: 34760721 2021 Frontiers in cellular and infection microbiology

Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,

Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.

PMID: 34764315 2021 Scientific reports

Result: All strains clustered under this group, including those sequenced in the current study, possessed the three GISAID clade G genetic variants, C241T, C3037T, and A23403G with an additional mutation C14408T.

Result: Based on the GISAID clade assignment, the samples detected during early April 2020 (4Apr20-3-Hu/2020 and 5Apr20-64-Hu/2020), and all samples detected in October 2020 (third epidemic wave) denoted clade G (Table 1), possessed genetic variations at C241T, C3037T, and A23403G.

Result: The A23403G was encoded for substitution of aspartic acid with glycine in the S-614 (S-D614G)

Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.

PMID: 34846283 2021 Microbial genomics

Result: Our samples contained SNVs in one of the early strain types (VI) that spread out of China (C241T, C3037T, C14408T and A23403G mutations) which has the haplotype of allelic associations 241T-3037T-14408T-23403G, detected in high frequency worldwide (December 2020), and that may be involved in increasing the fitness of the SARS-CoV-2 virus.

Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China.

PMID: 34917639 2021 Frontiers in medicine

Result: Eight single nucleotide polymorphisms (SNPs) were identified, including C242T, C313T, C3037T, C14408T, A23403G, G28881A, G28882A, and G28883C.

Discussion: A total of eight bases in the viral RNA sequence were mutated (referred to as: Gene Bank ID: MW301121) as follows: C241T, C313T, C3037T, C14408T, A23403G, and GGG28881AAC.

Discussion: We determined the Sichuan-2020 sequence belongs to haplogroup A2a4 (diagnostic variants: C241T<

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.

PMID: 34871297 2021 PloS one

Result: The mutation A23403G, known as D614G, was detected in genome sequences of two of our patients (ACUTG-1 and ACUTG-5).

Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.

PMID: 34866979 2021 Saudi journal of biological sciences

Conclusion: The SARS CoV-2 variants iso

Result: Our analysis showed that the most frequently changed nucleotide were C3037T (silent mutation) and A23403G (D614G) each of which occurred in 57 variants out of 58, followed by C14408T (P4715L) and C241T (5'UTR) which were found in 56 and 55 variants, respectively.

Result: The coexistence of C241T (5'UTR), C3037T (ORF1ab), C14408T (ORF1ab) and A23403G (S gene) was observed in 55 variants.

Genomic Epidemiology of SARS-CoV-2 in Pakistan.

PMID: 34695600 2021 Genomics, proteomics & bioinformatics

Result: Aside from this synonymous mutation, all C2 sequences carried other five m

Discussion: For example, the parent node sequences of C1 containing C2416T/C3037T/C14408T/A23403G/G25563T was reported to be associated with an international business conference in Boston, resulting in extensive international spread and low-level community transmission in Europe.

Discussion: Genomes of another sister cluster C2, harboring the C26735T variant in addition to common signatures of C3037T/C14408T/A23403G/C18877T/G25563T, have been found mainly in Asia (93 genomes as of October 9, 2020).

A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.

PMID: 34841355 2021 Current research in microbial sciences

Result: A total of 12 mutations were found in Germany in which four mutations 241C > T, 3037C > T, 14408C > T and 23403A > G were found common and existed at a frequency of 87.38%, 89.32%, 77.62% and 88.35%, respectively.

Result: After analyzing the samples of Brazil, a total of 12 mutations were found in which four of them (241C > T, 3037C > T, 14408C > T and 23403A > G) were identified at a frequency of 100%.

Result: Among all of these alterations originated from North America, South America and European regions, five SNPs (241C > T, 3037C > T, 14408C > T,

PMID: 34812411 2021 Informatics in medicine unlocked

Result: The A23403G mutation causes a change from Aspartate (D) to Glycine (G) in protein position 614 (spike protein) which is responsible for the initial entry of the virus through the ACE2 receptor and is associated with the severity of COVID 19.

Figure: The A23403G, C3037T, C14408T, and C241T are the most widespread mutations globally.

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