Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.
PMID: 32474553
2020
The Indian journal of medical research
Introduction: Another mutation, A23403G, located in the gene encoding the spike glycoprotein results in an amino acid change (D614G) from aspartic acid to glycine.
An updated analysis of variations in SARS-CoV-2 genome.
Abstract: Despite some variations being in low frequency rate in some continents, C14408T and A23403G variations on Nsp12 and S protein, respectively, observed to be the most prominent variations all over the world, in general, and both cause missense mutations.
Result: A23403G variation is one of the most important variations that have been reported previously (Phan et al., 2020) caused D614G substitution on S protein.
Result: As in the C14408T of Nsp12 variation, A23403G variation of S protein is also available in 70.46% frequency in SARS-CoV-2 genomes isolated all over the world (Fi
Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey.
Discussion: A23403G mutation in the spike glycoprotein coding region was also amongst the mostly seen mutations in viral isolates from Turkey (61%).
Discussion: A23403G substitution was found to be present in isolates from Europe and leads to an amino acid change from aspartate to glycine at position 614 (D614G) within the spike glycoprotein, where these amino acids differ by means of their isoelectric points (Pachetti et al., 2020).
Discussion: According to the linkage analysis, C241T, C3037T, C14408T and A23403G in Cluster 3 were in complete linkage and the TTTG h
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Result: At the end of January 2020, a nonsynonymous nucleotide change from the ancestral virus, A23403G, first appeared in virus genomes reported in China (hCoV-19/Zhejiang/HZ103/2020; 24 January 2020) and in Germany (hCoV-19/Germany/BavPat1-ChVir929/2020; 28 January 2020).
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.
Figure: Distribution of A23403G (D614G) Mutation and Other Mutations on an Approximate Phylogenetic Tree Using Parsimony, Related to Figure 7.
Figure: One is in the RdRp protein (nucleotide C14408T resulting in a P323L amino acid change), one in Spike (nucleotide A23403G resulting in the D614G amino acid change) and one is silent (C3037T).
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
7Figure: As an example, in this tree, the region from approximately 12:30 to 3 o'clock represents GISAID's ""GR"" clade, defined both by mutations we are tracking in this paper that carry the G614 variant (the GISAID G clade, defined by mutations A23403G, C14408T, C3037T, and a mutation in the 5' UTR (C241T, not shown here), and an additional 3-position polymorphism: G28881A + G28882A + G28883C."
RdRp mutations are associated with SARS-CoV-2 genome evolution.
Result: 23403A>G is a nonsynonymous mutation in the surface glycoprotein, while 3037C>T is a synonymous mutation in nsp3, a replication scaffolding protein.
Result: A recent study postulated that one of the co-mutations of 14408C>T, namely 23403A>G that causes D614G mutation in the S protein, may result in a more transmissible form of SARS-CoV-2.
Result: Despite weeks of existence, 23403A>G became the dominant form only after the appearance of the first Italian case with all four mutations on February 20.
Result: In contrast to Europe, North and South America, where 14408C>T became the dominant form together with
Comprehensive Analyses of SARS-CoV-2 Transmission in a Public Health Virology Laboratory.
Result: All samples sequenced were associated with clade 20, harboring the clade's mutations A23403G and C14408T (Nextstrain nomenclature).
Result: As specified, 7/14 mutations were associated with the 20B and 20C clades (Table 3), 4/14 mutations were detected in all sequences compared to the reference sequence (C241T, C3037T, C14408T, A23403G), and the rest of the mutations (3/14) were uniquely observed in S2, S3, S6, S7 and S8 (Table 3).
Discussion: Depending upon whether these mutations are beneficial for the virus, they may survive and be transmitted over time, for example, as occurred with the emerging clade 20-associated mutation A23403G/D614G that changed aspartate (acidic group) to gly
Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV-2.
Result: Another study reported that this variant has co-evolved with three coding region mutations (3037C > T, 14408C > T, and 23403A > G) of nsp3, RNA primase and spike glycoprotein.
Geographic and Genomic Distribution of SARS-CoV-2 Mutations.
5Result: Specifically, the four mutations C241T, C3037T, C14408T, and A23403G are observed in all samples from the clade ""G"" (named after the Spike D614G mutation) and its two derivative GH (further characterized by the ORF3a:Q57H mutation) and GR (affected by the trinucleotide mutation in the Nucleocapsid gene, inducing a RG203KR mutation)."
Result: The most prevalent mutation in sequenced genomes worldwide is a transversion affecting the 23,403rd nucleotide adenosine (Supplementary File 6), transformed into a guanosine (A23403G), defining the so-called G-clade of SARS-CoV-2 genomes, prevalent in Europe (where overall the highe
SARS_CoV_2 mutation literature information.
PMID: 
2020
The Indian journal of medical research
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