Result: Among SARS-CoV-2 sequences reported from Bangladesh, 241C > T, 3037C > T, 14408C > T, 23403A > G, 28881G > A, and 28883G > C mutations were the six most abundant nucleotide mutations that occurred in 98% sequences.
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: By June 2020, barely six months into the pandemic, the L clade dwindled to only 7% outside of Asia, and the dominating sequence group became the rapidly evolving G clade harbouring, amongst other changes, the D614G mutation in the viral spike protein (base change: A23403G, reference sequence: EPI_ISL_450201).
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Abstract: Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to life-threatening mutations.The spike D614G amino acid change has become the most common variant since December 2019.
Result: Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to miserable mutations.The spike D614G amino acid change has become the most common variant since December 2019.|mgd
Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021.
Introduction: This variant contains a mutation from A to G at nucleotide 23403, resulting in amino acid change from aspartic acid to glycine at residue 614 of the spike protein, which appeared to increase viral infectivity and transmissibility.
Abstract: Reverse transcription fluorescence resonance energy transfer-polymerase chain reaction (FRET-PCRs) were designed against the two most common mutations in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (A23403G in the spike protein; C14408T in the RNA-dependent RNA polymerase).
Method: Genomic RNA of two SARS-CoV-2 viruses from american type culture collection (ATCC) served as controls and as quantitative standards: 2019-nCOV/USA-WA1/2020 which does not contain the A23403G and the C14408T mutations, and 201/501Y.V1 which contains both mutations.
Method: The 6-carboxyfluorescein (6-FAM)-labeled probes were further designed to contain the unique A23403G or PMID: 34141447
2021
Virus evolution
Result: Several non-synonymous variations are found differential between cluster A and B, for example, C14408U, A23403G, and G28881A-G28882A-G28883C resulting in Nsp12 P323L, S protein D614G, and N protein R203K-G204R, were found differ, respectively (Table 2).
Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.
PMID: 34154921
2021
Journal of infection and chemotherapy
Abstract: METHODS: We investigated five mutation sites, A23403G, G25563T, G26144T, T28144C, and G28882A, which are known strain determinants according to GISAID clades (L, S, V, G, GH, and GR).
Method: pMA vectors harboring a series of five wild-type DNA fragments (A23403, G25563, G26144, T28144, and G28882) and mutants (A23403G, G25563T, Result: DNA templates were amplified from pre-prepared pMA vectors harboring five mutational sites (A23403G, G25563T, G26144T, T28144C, and G28882A; Table 1), before proceeding to HRM analysis.
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.
PMID: 34157472
2021
Computers in biology and medicine
Table: 23403A>G
The architecture of the SARS-CoV-2 RNA genome inside virion.
Result: Interestingly, we found that the A23403G mutation fine-tuned the two local bulge structures into a thermodynamically more favorable six-nucleotide bulge structure (-10.3 kcal/mol vs.
Figure: The C241U, C3037U, C14408U, and A23403G (D614G) mutants are marked as solid lines.
SARS-CoV-2: Origin, Evolution, and Targeting Inhibition.
PMID: 34222046
2021
Frontiers in cellular and infection microbiology
Introduction: As for the A23403G, it encodes the mutant D614G in Spike protein.
Introduction: In these SNPs, four SNPs, C3037U, C14408U, A23403G, and C241U, show high frequency.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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